白细胞介素4在儿童原发性肾病综合征中增高及其意义  

INCREASED PRODUCTION OF IL - 4 ANDITS SIGNIFICANCE IN CHILDREN WITH INS

作　　者：康健[1] 白克敏[1] 王宝琳[1] 姚智 庞学文 陈慰峰 

机构地区：[1]北京医科大学第一医院儿科,北京医科大学免疫教研室

出　　处：《中华肾脏病杂志》1994年第5期271-273,322-323,共5页Chinese Journal of Nephrology

摘　　要：对４４例原发性单纯型肾病综合征患儿及２８例相应性别、年龄的健康儿童的过敏史、血清免疫球蛋白Ｅ类（ＩｇＥ）及Ｔ辅助细胞分泌的白细胞介素４（ＩＬ一４）进行研究。发现：患儿既往和家族过敏史均高于健康儿童；ＩｇＥ和ＩＬ一４在极期均明显增高，且两者呈显著性直线正相关；ＩＬ一４与２４小时尿蛋白也呈显著性正相关。提示：Ｔ辅助细胞活化后分泌的高水平ＩＬ一４可能是ＩｇＥ增高的原因；ＩＬ一４有可能参与了导致蛋白尿的病理过程，但尚须进一步证明。erum and peripheral blood mononuclear cells(PBMC) were collected from 44 children with simpletype ldiopathic Nephrotic Syndrome (INS) aged from1. 5 to 14 year old and 28 age and sex-matchedhealthy children. Serum IgE and the level of inter-leukin 4 (IL - 4) in supernatant of PHA activatedPBMC were tested by ELISA. Our study revealed ahigh incidence of allergic diseases in INS children andtheir first degree relatives and a close association be-tween atopy and INS. Besides, the serum IgE and IL-4 were highly raised in exacerbation (P<0. 001 ,both) ; IgE returned normal, IL- 4 was slightly low-er in remission (P>0. 2, p<0. 0l respectively). Apositive corelation between IgE and IL- 4, IL- 4and quantity of proteinuria in 24 hours was noticed(r=0. 472 , r= 0. 562; P<0. 05, P<0. 0l respective-ly). These indicated that a close relationship betweenatopy and INS existed indeed. Both IL- 4 and IgE.the important mediators in atopy, showed abnormalchange in patients and, the increased IL- 4 produc-tion in T cells rnay account for the elevated IgE level.Furthermore, IL- 4 may have an effect in pathogen-esis in INS, but it still reniained speculative.

关 键 词：肾病综合征 白细胞介素4 免疫球蛋白E类 

分 类 号：R692.03[医药卫生—泌尿科学]