Graves病患者骨密度与血AKP、尿羟脯氨酸的变化  

Changes or Bone Mineral Density,Serum AKP and Urine Hydroxyproline in Graves′Disease

作　　者：潘时中[1] 严孙杰[1] 王敏[1] 赵淑好[1] 刘东晖 张松菁[1] 陈鸿基[1] 

机构地区：[1]福建医学院附属第一医院内科,福建医学院预防医学系

出　　处：《福建医科大学学报》1994年第4期340-342,共3页Journal of Fujian Medical University

基　　金：福建省卫生厅科研课题

摘　　要：测定２３８例Ｇｒａｖｅｓ病患者和１２８例正常人的骨密度（ＢＭＤ）以及血三碘甲腺原氢酸（Ｔ＿３）、血清钙（Ｃａ）、磷（Ｐ）、碱性磷酸酶（ＡＫＰ）、尿羟脯氨酸（ＨＹＰ）。结果：Ｇｒａｖｅｓ组ＢＭＤ明显低于正常组（Ｐ＜０．０１），６０．２％患者有ＢＭＤ降低表现，＞４０岁组与正常组比有明显差异（Ｐ＜０．０１）；Ｇｒａｖｅｓ组尿ＨＹＰ与正常组比有非常显著差异（Ｐ＜０．０１）；Ｇｒａｖｅｓ患者中ＢＭＤ降低者，桡、尺骨Ｘ线摄片均正常。A determination of bone mineral density,serum tridothyronime(T3),serum calcium(Ca),serum phosphorus P),serum alkaline phosphatease(AKP),and hydroxyproline in urine from 238 patients showed:BMD in Graves′group was significantly lower than that in normal control group(P<0.01).The BMD in 60.2%of the patients descended.HPY in urine also showed considerable significant difference(P<0.01).In patients whose BMD descended however roentgenograms of radius and ulna were normal.

关 键 词：GRAVES病 尿羟脯氨酸 骨密度 骨代谢 

分 类 号：R581.1[医药卫生—内分泌]