双叶抗栓素抗血栓形成作用的研究  

Study on Antithrombotic Effect Shuang Xie Kang Shuan Su

作　　者：刘泽霖[1] 谭获[1] 刘敏涓[1] 冯莹[1] 关东文[1] 张薇[1] 

机构地区：[1]广州医学院附属二院,血液学研究室,广州510260

出　　处：《血栓与止血学》1994年第1期6-8,共3页Chinese Journal of Thrombosis and Hemostasis

摘　　要：本文报道了五叶参、桑叶抗血栓形成的新作用。通过体外实验研究证实,五叶参、桑叶水煮制备液能明显抑制ADP、复合诱聚剂诱导的血小板1分、5分、最大聚集率,并促进解聚发生(P均<0.05):二种药物还对体外血栓形成具有显著的抑制作用(P均<0.05;五叶参、桑叶与PPP混合后,尚能抑制多种凝血因子活性.使KPTT、PT、TT、AT、RVV-RT、RVV-CT等凝血试验时间延长(P均<0.05);此外.二种药物皆可加速红细胞电泳速度。上述结果表明,五叶参、桑叶是二种具有抑制血小板功能、凝血象及红细胞聚集性等多个环节的抗血栓形成药物,值得进一步研究探讨。Human blood samples were investigated in vitro to observe the antithrombotic effect of water extract of Gy-nostemma pentaphyllum and Moms alba L, these two kinds of Chiness herb medicines are called Shuan Xie Kang Shuan Su, (SXKSS). The results showed that SXKSS could inhibit significantly the platelet aggregation induced by ADP and compound agonists (P<0. 05) , accelerate obviously the disaggregation (P<0. 05) and inhibit effectively the experimental thrombosis (P<0. 05). The delayed effects of SXKSS on KPTT, PT, TT, AT, RVV-RT, RVV-CT suggested that these drugs could decrease the activity of multiple coagulation factors. And it showed that SXKSS could accelerate the ery-throcyte electrophoresis rate. This study revealed that Gynostemma pentaphyllum and Morus abla L are two kinds of antithrombotic agents affecting the links of thrombotic chain which are worthwhile to be studied further.

关 键 词：五叶参 桑叶 血栓 

分 类 号：R285[医药卫生—中药学]