Studies on Enantioselective Effect of Chiral Titanate Reagents on the Synthesis of Substituted Benzhydrols  

作　　者：WANG Ji-tao FAN Xiu-ju, FENG Xiao and LI Yue-ming (Department of Chemistry, Nankai University, Tianjin, 300071) 

出　　处：《Chemical Research in Chinese Universities》1993年第1期28-34,共7页高等学校化学研究（英文版）

基　　金：Supported by the Grant of National Natural Science Foundation of China ; the Organometallic Chemistry Laboratory of the Shanghai Institute of Organic Chemistry, Chinese Academy of Science

摘　　要：Chiral titanate reagents were prepared for inducing asymmetric syntheses of substituted benzhydrols from Grignard reagents and aldehydes. The solvents, reaction temperature and exchange of reactants by crossing experiments were investigated. Favorable attack of the nucleophile upon the aromatic aldehydes' prochiral face was proposed, the absolute configurations of the synthesized benzhydrols were suggested, and a preliminary reaction mechanism was described.Chiral titanate reagents were prepared for inducing asymmetric syntheses of substituted benzhydrols from Grignard reagents and aldehydes. The solvents, reaction temperature and exchange of reactants by crossing experiments were investigated. Favorable attack of the nucleophile upon the aromatic aldehydes' prochiral face was proposed, the absolute configurations of the synthesized benzhydrols were suggested, and a preliminary reaction mechanism was described.

关 键 词：Asymmetric synthesis Benzhydrols Chiral titanates 

分 类 号：O6[理学—化学]