人参抗动脉粥样硬化作用的实验研究——EPMA检测细胞内原位钙含量  

Experimental Study on the Anti-atherosclerotic Effects of Panax Ginseng——Measuring Intracellular in situ Calcium Content with EPMA

作　　者：徐泽昌[1] 刘红英[2] 董振南[2] 张德添[3] 汪宝珍[3] 杨毅[3] 张学敏[3] 

机构地区：[1]北京军区总医院 [2]解放军总医院,北京100853 [3]军事医学科学院,北京100853

出　　处：《中药药理与临床》1993年第2期27-29,共3页Pharmacology and Clinics of Chinese Materia Medica

摘　　要：30只兔分为正常对照组、动脉粥样硬化对照组和人参组。检测血MDA、6-酮-PGF_1^a、TXB₂及主动脉壁中层平滑肌胞质原位钙含量等。结果人参无明显抗动脉粥样硬化作用,无阻止细胞内钙超负荷作用。Thirty male New Zealand white rabbits were randomized into 3 groups: normal control group (C) , control group for atherosclerosis (CAS) and Panax ginseng treated group (G) . The experiment lasted for 12 wks. Results: The blood total cholesterol, MDA, TXB2 and in situ calcium content in the cytoplasm of the aortic medial smooth muscle cells (measured with electron probe microanalysis) in group CAS were all markedly higher than those in group C (P<0.05 or 0.01). Ginseng had no inhibitory effect on the increment of those described above. The area of intimal plaques in group G and CAS was 26±7% and 44±8%, respectively. The difference between these two groups was not significant (P>9.05). Although it was reported that Panax ginseng has some anti-atherosclerotic properties, the present study showed no obvious inhibitory effect of ginseng on atherogenesis in vivo.

关 键 词：人参 动脉粥样硬化 电子探针微分析 细胞内原位钙 

分 类 号：R28[医药卫生—中药学]