何首乌中二苯乙烯甙在兔体的药代动力学  

PHARMACOKINETICS OF STILBENE GLVCOSIDE FROM POLYGONUM MULTIFLORUM THUMB IN RABBITS

作　　者：黄坚[1] 李仪奎[1] 李占宁 

机构地区：[1]上海中医学院中药系药理研究室,上海20032

出　　处：《中药药理与临床》1993年第5期32-34,36,共4页Pharmacology and Clinics of Chinese Materia Medica

摘　　要：用一阶导数分光光度法测定血浆样品中二苯乙烯甙的含量和何首乌中二苯乙烯甙在兔体内药动学的研究。方法的线性范围为0.1～10μg/ml,测定样品中二苯乙烯甙的平均回收率为93±2％(n=5)。兔一次快速iv(25mg/kg)及po(120mg/kg)二苯乙烯甙后血浆的药时曲线均符合二室开放模型。药动学参数为iv:t_(1/2)α=4.1min,t_(1/2)β=1.28h,K_(21)=2.190h^(-1),K_(12)=6.034h^(-1),K_(10)=2.520h^(-1),Vd=0.916L/Kg,V_c=0.197L/kg,CL=0.495L/h/kg,AUC=50.46mg·h/L;po:t_(1/2)Ka=1.06h,t_(1/2)α=2.15h,t_(1/2)β=9.70h,Vd=6.93L/kg,Vc=3.32L/kg,K_(21)=0.1546h^(-1),K_(12)=0.09025h^(-1),K_(10)=0.1491h^(-1),T_P=2.55h,Cmax=6μg/mL,CL=0.495L/h/kg,AUC=70.53mg·h/L,生物利用度为29.1％。A method has been proposed to determine stilbene glycoside in plasma samples by first derivative spe-ctrophotometry. Assay linearity was demonstrated over the range of 0. 1 ~ 1 0μg/ml with a regression coefficient of 0. 9996. The determination for stilbene glycoside in plasma samples showed an average recovery of 93±2% and the coefficient deviation of less than 2%. At the same time, it is used to study on pharmacoki-netics of stilbene glucoside in rabbits. The plasma drug concentration-time curve was shown to fit a two-compartment open model after a single intravenous injection (25mg/kg) or oral (120 mg/kg) of stilbene glycoside to rabbits. The pharmacokinetic parameters for iv are t1i/2α= 4.1 min, t1/2β=l. 28 h, K21 = 2.190h-1, K12 = 6.034 h-1, K10 = 2.520 h-1, Vd = 0. 916 L/kg, Vc=0. 197L/kg, CL=0. 495 L/h/kg, AUC=50. 46 mg · h/L,and for po t1/2ka=l. 06 h, t1/2α=2. 15h, t1/2β=9. 70h,K2, = 0. 1546 h-1, K12 = 0. 09025 h-1, K10=0. 1491 h-1, Vd = 6. 93 L/kg, Vc=3. 32 L/kg, T9=2. 55 h, Cmax = 6 μg/ml, CL= 0. 495 L/h/ke, AUC=70. 53 mg·h/L. The fraction of drugs absorbed for DO is 29. 1 %

关 键 词：二苯乙烯甙 何首乌 药代动力学 一阶导数分光光度法 

分 类 号：R28[医药卫生—中药学]