Study on Coenzyme B_(12) Model Compounds by Electrochemistry and Quantum Chemistry  

作　　者：高德 郑国栋 高赛 曹锡章 

机构地区：[1]Department of Chemistry and Chemical Engineering, Hunan University, Changsha 410082 PRC [2]Department of Chemistry, Jilin University, Changchun 130023 PRC

出　　处：《Chinese Science Bulletin》1993年第12期998-1001,共4页

基　　金：Project supported by the National Natural Science Foundation of China

摘　　要：It is now widely recognized that coenzyme B₁₂-dependent rearrangements are caused by homolytic dissociation of the Co-C bond giving rise to a 5’-deoxyadenosyl radical. The Co-C bonding strength is related to the electronic and steric effect of the 5’-deoxyadenosyl radical and the axial organic base, playing a key role in the catalytic cycle. To clarify the mechanism of Co-C bond breaking in coenzyme B₁₂, many experimental and theoretic researches on B₁₂ model compounds have been conducted, especially on the

关 键 词：COENZYME B₁₂ model compounds ELECTROCHEMISTRY quantum chemistry. 

分 类 号：N[自然科学总论]