Norplant皮下埋植对脂代谢的影响  

Effect of Norplant on Lipid Metabolism.

作　　者：赵晋华[1] 郝秋芳[1] 王玮[1] 陈昌榕[2] 陶若愚[2] 

机构地区：[1]山西医学院第一附属医院妇产科 [2]山西省人民医院妇产科

出　　处：《中国计划生育学杂志》1993年第5期272-274,320,共4页Chinese Journal of Family Planning

摘　　要：本研究旨在观察Norplant对脂代谢的影响,对象为85例皮下埋植该药1～5年的妇女。测定空腹血清甘油三酯（TG）、总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）、HDL-C的亚组分HDL₂-C、HDL₃-C,载脂蛋白A₁、B（apoA₁、B）的水平,计算出低密度脂蛋白胆固醇（LDL-C）、HDL-C/TC、HDL-C/LDL-C。结果显示:与对照组相比,TG及apoA₁显著降低;预测心血管疾病较可靠的指标 HDL-C/TC、HDL-C/LDL-C、apoA₁/apoB无显著变化。本研究提示:皮下埋植Norplant对脂代谢影响轻微。The study of the effect of Norplant on Lipid metabolism in eighty-five women using Norplant for one to five years was reported. Triglycerides(TG), total cholesterol(TG), high density lipoproteins-cholesterol(HDL-C, HDL_2-C, HDL_3-C) levels in fasting serum were measured by enzymatic method. Apolipoproteins A_1, B (apoA_1, B) levels were determined by rocket-immunoelec-trophoresis, The present data showed that in different-year groups TG decreased significantly(p<0.05～p<0.01) and apoA_1 decreased for 11%～18%(p<0.05), when compared to the control group. However, the ratios of HDL-C/TC, HDL-C/LDL-C, apoA_1/apoB were not changed significantly. The result implies that the effect of Norplant on lipid metabolism is slight.

关 键 词：NORPLANT 皮下埋植 脂代谢 

分 类 号：R169[医药卫生—公共卫生与预防医学]