肾小球疾病患者血清Ⅳ型胶原测定的临床意义  

Clinical significance of serum type Ⅳ collagen concentration in glomerular diseases

作　　者：范敏华[1] 朱宁[1] 廖新[1] 韩庆烽[1] 寇丽筠[2] 张捷[2] 邹万忠[3] 

机构地区：[1]北京医科大学第三医院肾内科,100083 [2]北京医科大学第三医院肾检验科,100083 [3]北京医科大学第三医院肾病理科,100083

出　　处：《肾脏病与透析肾移植杂志》1993年第3期210-212,共3页Chinese Journal of Nephrology,Dialysis & Transplantation

摘　　要：本文应用单克隆抗体免疫法检测了53例健康人及50例不同病期的肾小球疾病患者血清Ⅳ型胶原水平,并与肾活检组织病理所见进行了比较。结果显示,肾功能受损害者血清Ⅳ型胶原水平明显高于正常人,且与肾单位损害的严重程度密切相关.提示Ⅳ型胶原的代谢变化在肾小球疾病进行性发展过程中起着重要作用.血清Ⅳ型胶原水平的测定,可以作为临床监测肾小球疾病活动及病程进展的有用指标。Serum levels of type Ⅳ collagen (Ⅳ. C) were measured using one step sand wish enzyme immunoassay in 50 patients with glomerular diseases and compared with pathologic changes and serum BUN,SCr. The results showed that serum levels of Ⅳ. C on pathogenisis and the serum level of Ⅳ. C seemed to be a useful,noninvasive and reproducible biochemical marker for monitoring the activity or progression of glomerular disease.

关 键 词：Ⅳ型胶原 肾小球硬化 细胞外基质 

分 类 号：R5[医药卫生—内科学]