老年人血糖增高与细胞免疫功能的关系  

Relationship between Increase of Serum Glucose and Cell--Mediated Immunological Function in the Elderly

作　　者：杨志援[1] 郭实士[2] 谭孝厚[1] 杨卫星 吴克前[1] 

机构地区：[1]湖南医科大学附属湘雅医院 [2]湖南医科大学免疫研究室

出　　处：《中华医院感染学杂志》1993年第3期132-135,共4页Chinese Journal of Nosocomiology

摘　　要：本文测定了35例老年高血糖患者和30例健康老年人外周血自然杀伤细胞(NK)、白细胞介素-2(IL-2)和免疫干扰素(IFNr)活性。结果表明,高血糖组NK、IL-2活性均较健康对照组显著降低;其中并发其他感染者的血清葡萄糖水平明显高于非感染者(p<0.05),而NK,IL-2活性则低于非感染者。血糖浓度与IL-2,NK活性均呈负相关;NK和IL-2活性呈正相关。提示,高血糖可能抑制老年细胞免疫功能,易发医院感染。Peripheral blood natural killer cell (NK),interleukin2(IL-2) and interferon(IFN)activities of 35elderly patients with hyperglycemia and 30 healthy el-derly persons were determined. The results showedthat: compared with healthy group, NK and IL-2 ac-tivities were statistically significant decreases inhyperglycemia group; among hyperglycemia patients,compared with no complicated infection group, NKand IL-2 activities were statistically significant de-creases, and level of serum glucose was statisticallysignificant increase in complicated infection group.The findings implied that hyperglycemia might sup-press cell-mediated immunological function, whichmight increase the risk susceptive to nosocomial infec-tion.

关 键 词：高血糖症 老年人 自然杀伤细胞 白细胞介素-2 免疫干扰素 

分 类 号：R197[医药卫生—卫生事业管理]