慢性肺心病并发多器官衰竭时血浆血栓素 B_2和6-酮-PGF_(1α)的变化观察  

Changes of plasma level of TXB_2 and 6-keto-PGF_(1α)in patients with cor pulmonale complicated with multiple organ failure

作　　者：杨和平[1] 吴善[1] 沈寒放[1] 陈云远 王新华 艾卫东 

机构地区：[1]第三军医大学第一附属医院呼吸科

出　　处：《中国危重病急救医学》1991年第2期67-69,127,共4页Chinese Critical Care Medicine

摘　　要：本文动态观察了肺心病患者并发多器官衰竭(MOF)时和非多器官衰竭(NMOF)时血浆血栓素 B_2(TXB_2)和6-酮-PGF_(1α)的变化。结果发现,MOF 组和 NMOF 组患者急性期血浆 TXB_2、TXB_2/6-keto-PGF_(1α)值均明显增加,而6-keto-PGF_(1α)则明显减少,与缓解期比较均有显著差异。且急性期 MOF组血浆 TXB_2、TXB_2/6-keto-PGF_(1α)值的增加与 NMOF 组比较亦有显著差异。提示 TXA_2-PGI_2平衡失调可能是肺心病 MOF 发生发展的病理生理基础之一。The changes of plasma levels of thromboxane B_2 (TXB_2)and 6-keto-PGF_(1α) were observed in the patients with cor pulmonale complicated and not complicated with multiple organ failure(MOF and NMOF).It was found that plasma TXB_2 and TXB_2/6-keto-PGF_(1α) ratio were significantly increased,while 6-keto-PGF_(1α) significantly decreased during the acute stage of the disease in both groups compared with the remssion stage.Moreover, plasma TXB_2 level and TXB_2/6-keto-PGF_(1α) ratio mea- sured in the MOF group during the acute stage were sig- nificantly higher thana NMOF group.It is suggested that the imbalance of TXA_2 and PGI_2 may play an important role in the genesis and development of MOF in patients with cor pulmonale.

关 键 词：肺心病 多器官衰竭 血栓素 A₂ 前列腺素类 

分 类 号：R4[医药卫生—临床医学]