“神农33”对感染性休克家兔红细胞超氧化物歧化酶和血清过氧化脂质水平变化的影响  

Effects of Shen Nong No.33 on changes of red blood cell superoxide dismutase and serum lipid peroxide levels in rabbits with septic shock

作　　者：李志军 张碧丽[2] 李明润 王瑛 李明 王今达 

机构地区：[1]天津市急救医学研究所 [2]天津市儿童医院 [3]天津市药物研究所

出　　处：《中国危重病急救医学》1991年第2期94-96,129,共4页Chinese Critical Care Medicine

摘　　要：为了进一步探讨感染性休克介导的 MSOF 的发病机制及防治措施,将感染性休克家兔分为中药治疗组和非中药治疗组,动态监测了红细胞超氧化物歧化酶及血清过氧化脂质水平变化。结果表明:红细胞 SOD 的下降以及 LPO 对细胞膜结构的损伤,是感染性休克介导的 MSOF 的重要发病机制之一。神农33号中药静脉注射剂对此有显著的防治作用。In order to further explore the mechanism,predven- tion and treatment of multiple system organ failure (MSOF)induced by septic shock,the changes of the lev- els of serum lipid peroxide(LPO)and red blood cell su- peroxide dismutase were continuously observed in two groups of rabbits with septic shock treated and not treated with traditional Chinese medicine.The result shows that the decrease of red cell superoxide dismutase and the damage to cytomembranaae structure caused by LPO is one of the important pathogentic factors of MSOF in- duced by septic shock,and the traditional Chinese medicine named“Shen Nong No.33”injection plays a remarkable role in the prevention and treatment of MSOF induced by septic shock.

关 键 词：“神农33号中药” 超氧化物歧化酶(SOD) 过氧化脂质(LPO) 多系统脏器衰竭(MSOF) 

分 类 号：R4[医药卫生—临床医学]