硝苯吡啶与巯甲丙脯酸联合治疗高血压疗效观察  

Observation on Combined Effect of Nifedipine and Captopril in Treatment for Hypertension

作　　者：李彩英[1] 王西平[1] 梅克治[1] 黎秀墀 何叶熊 

机构地区：[1]广州市红十字会医院心内科 [2]广东医药学院诊断学教研室

出　　处：《广东药学院学报》1990年第2期42-44,共3页Academic Journal of Guangdong College of Pharmacy

摘　　要：本文报告使用硝苯吡啶与巯甲丙脯酸联合治疗高血压90例,90例中原发性高血压缓进型83例,(其中伴有心衰者19例),肾实质性高血压6例,(其中伴有心衰者2例),多发性大动脉炎1例。病程1—25年,平均8.9年,治疗一天总有效率50％(P<0.05),治疗三天总有效率87.8％(P<0.01),治疗7天总有效率96.6％(P<0.01),伴心衰者21例均于用药后2—3天明显改善。未发现明显和严重的副作用,认为是治疗高血压较理想的配伍方法,对高血压伴有心衰者尤为适用。In this article the combined effect of nifedipine and captopril was reported in treatment for 90 cases of hypertension including 83 cases of primary hypertension (19 cases of which associated with heart failure), 6 cases of renovascular hypertension (2 cases of which associated with heart failure) ,and 1 case of polyaorto arteritis. Patients ranged in medical history from 1 to 25 years with a medium of 8.9 years . The total effective rate was 50%(P<0.05) for one-day,87.8%(P<0.01) for three-day and 96. 6%(P<0. 01 )for seven-day treatment. Symptomatic improvement had been observed in 21 patients associated with heart failure after 2-5 day treatment. No marked or severe side effect was found. It is suggested that nifedipine add captoprl is a rational combination in treatment for hypertension , especially for this disease associated with heart failure.

关 键 词：硝苯吡啶 巯甲丙脯酸 高血压 心衰 

分 类 号：R9[医药卫生—药学]