丹参素、黄芩甙等对大鼠腹腔巨噬细胞产生PGE_2及TXB_2的影响  

Pharmacological Regulation of PGE_2 and TXB_2 Production by Rat Peritoneal Macrophages

作　　者：张罗修[1] 王梦[1] 钱芸 曹致芳[1] 梅美珍 易鸿匹 

机构地区：[1]上海医科大学药学院药理教研室,上海200032

出　　处：《中药药理与临床》1990年第4期31-34,共4页Pharmacology and Clinics of Chinese Materia Medica

基　　金：中国科学院基金资助课题

摘　　要：酵母多糖刺激大鼠腹腔细胞合成与释放PGE_2及TXB_2,经短期培养(0～4h),静止的细胞合成的PGE_2虽随时间的延长而增加,但无显著差别,而TXB_2的增长有明显差别。经酵母多糖刺激后二者均有显著增加,但以TXB_2之增加更迅速。角叉菜、硅胶、钙离子载体A_(23187)均能显著促进培养24h的腹腔巨噬细胞合成与释放PGE_2和TXB_2。消炎痛、丹参素、硝苯吡啶及黄芩甙明显抑制A_(23187)诱导的PGE_2合成增加。PGE2 has been recognized as an important mediator derived from macrophage in response to inflammatory stimulus. Among the cells involved in immune responses macrophage is the major cell to synthesis PGE2 and TXB2. The production of PGE2 and TXB2 can be regulated by different agents. In this study, elicited rat peritoneal macrophage cultured with or without different agents for certain hours then the culture fluids were assayed for PGE2 and TXB2 by radioimmuno assay after extracted with acetic ester. It has been shown that rest macrophages released little PGE2 but TXBz increased more rapidly than PGE2 in a time dependent fasion for 0-4 hours. After stimulation of zymosan for 0-4 h,the level of PGE2 and TXB2 were increased in the same fasion. Carrageenan, silica, A stimulated macrophage to increase PGE2 and TXB2 production. However, indomethacin danshensu, nifedipine and baicalin all inhibited PGE2 production by macrophages induced by

关 键 词：PGE₂ TXB₂ 酵母多糖 角叉菜 A₂₃₁₈₇ 硅胶 丹参素 黄芩甙 硝苯吡啶 巨噬细胞 

分 类 号：R28[医药卫生—中药学]