Studies on Preclinical Toxicology of a New Tumor Photolocalizing and Photochemotherapeutic Agent, Photocarcinorin(PsD-007)  

作　　者：沈念慈 袁伯俊 唐惠兰 李保春 刘俊平 李燕平 张璞 

机构地区：[1]Laboratory for Antimalarial Drug Research and Department of Pathologic Anatomy [2]Second Military Medical University,Shanghai 200433

出　　处：《Journal of Medical Colleges of PLA(China)》1990年第3期215-221,226,共8页中国人民解放军军医大学学报（英文版）

摘　　要：Photocarcinorin was prepared in our Lab and its composition was differentfrom that of any other hematoporphyrin photosensitizers by TLC and HPLC analyses.The 95% fiducial limits of iv LD in mice were 176-236 mg·kg^-1.The iv MLD indogs was 171 mg·kg^-1.The acute and subacutc toxic tests in 37 dogs showed that theintoxicated manifestations were characterized by a complex syndrome always seen inporphyrias.The biological,laboratory and histopathologic findings revealed that theliver,kidney and erythroeytic series were the target organs.The damages were dose-related and reversible within 2 wk.he phototoxicity was determined in mice with UV ra-diation and compared with that of HpD.The extent of its phototoxic reactions waslower than that of HpD’s.Photocarcinorin was prepared in our Lab and its composition was different from that of any other hematoporphyrin photosensitizers by TLC and HPLC analyses. The 95% fiducial limits of iv LD in mice were 176-236 mg·kg^(-1).The iv MLD in dogs was 171 mg·kg^(-1).The acute and subacutc toxic tests in 37 dogs showed that the intoxicated manifestations were characterized by a complex syndrome always seen in porphyrias.The biological,laboratory and histopathologic findings revealed that the liver,kidney and erythroeytic series were the target organs.The damages were dose- related and reversible within 2 wk.he phototoxicity was determined in mice with UV ra- diation and compared with that of HpD.The extent of its phototoxic reactions was lower than that of HpD's.

关 键 词：PHOTOCARCINORIN PSD-007 hematoporphyrins PHOTOSENSITIVITY disorders HEMATOLOGIC TESTS liver FUNCTION TESTS kidney FUNCTION TESTS enzyme test 

分 类 号：R[医药卫生]