甲醛接触对工人肺功能的影响  

Effects of Occupetional Formaldehyde Exposure on Pulmonary Function

作　　者：蒋学之[1] 张瑞稳[1] 王英[1] 袁家牛 

机构地区：[1]上海医科大学劳动卫生学教研室

出　　处：《中国工业医学杂志》1990年第1期12-15,64-65,共6页Chinese Journal of Industrial Medicine

摘　　要：对430名受试者进行了肺功能测定,主要为FEV_(1.0)、FVC和FEV_(1.0)/FVC。根据空气中甲醛浓度分为三组;Ⅰ组(空气中甲醛0.70±0.24mg/m^2)、Ⅱ组(1.45±1.30mg/m^3)、Ⅲ组(2.97±2.01mg/m^3),另以无毒物接触史者作对照组。多因素分析表明,接触甲醛高于1mg/m^3可致FEV_(1.0)和FEV_(1.0)/FVC下降,并与接触工龄相关。FEV_(1.0)/FVC异常率在Ⅲ组明显增加,提示接触浓度在3mg/m^3对肺功能有较明显影响。Pulmonacy function tests, including mea-suremenz of forced vital capacity (FVC), (one--second forced expiratory volume (FEV_(1.0)) ,and the ratio of FEV_(1.0) over FVC (FEV_(1.0)/FVC, %), were administered to 319 formal-dehyde-exposure workers and Ⅲ controls.The former was divided into 3 subgroups,based on their exposure levels, including sub-group Ⅰ(formaldehyde in air, HCHO-A=0.70±0.24mg/m^3), subgroup Ⅱ (HCHO-A=1.45±1.30mg/m^3), and subgroup Ⅲ (HCHO-A=2.97±2.01mg/m^3) . Workes exposed to formaldehyde atlevels more than 1mg/m^3 of formaldehydehad lower FEV_(1.0)/FVC ratios than thosenon-exposed. Analysis of stepwise re-gression indicated that the FEV_(1.0) ofexposurer was negatively correlated withexposure level and the FEV_(1.0)/FVC ratiosnegatively correlated with exposure duration.The abnormality in terms of FEV_(1.0)/FVCratios (less than 83%) in group Ⅲ was higher than that of control, but those in group Ⅰ andgroup Ⅱ were not. The results suggested thatthe chronic airway obstruction existed amongworkers exposed to formaldehyde at levelsabout 3mg/m^3.

关 键 词：甲醛 肺功能 多因素分析 

分 类 号：R13[医药卫生—劳动卫生]