5种伊维菌素注射液在家兔体内的比较药动学研究  

Compare Pharmacokinetics of 5 Different Ivermectin Injection in Rabbit

作　　者：张瑞丽 崔亮亮 郝智慧[1,2] 赵永达 

机构地区：[1]青岛康地恩药业有限公司,山东青岛266111 [2]中国农业大学动物医学院,北京100193

出　　处：《中国畜牧兽医》2011年第11期188-190,共3页China Animal Husbandry & Veterinary Medicine

基　　金：国家火炬计划"新型系列动物药物产业化项目"(2008GH021319)

摘　　要：试验旨在研究5种不同处方的伊维菌素注射液在家兔体内的比较药动学特征。50只健康家兔随机分为5组,通过单次给药剂量(5mg/kg体重)皮下注射伊维菌素注射液,3P97药动学计算软件处理血浆药物浓度—时间数据。家兔皮下注射伊维菌素注射液属于一级吸收一室开放模型。自制伊维菌素注射液的:T1/2(Ka)(8.10±3.68)h、T1/2(Ke)(36.34±14.63)h、Tmax(22.38±8.63)h、Cmax(354.01±57.75)ng/mL、AUC(25843±3029)ng/(mL.h)。经SPSS统计学分析软件分析显示自制伊维菌素注射液的T1/2(Ka)、T1/2(Ke)无显著性差异,但Cmax分析显示与C、D存在显著性差异(P<0.05),与A、B无显著性差异(P>0.05),但明显高于A、B的Cmax。AUC平均值明显高于其余4种,说明自制伊维菌素注射液在家兔体内具有吸收好,消除快,生物利用度高等优点,临床可安全使用,具有更好的抗寄生虫作用。The pharmacokinetics was investigated and compared in 50 healthy rabbits following single subcutaneous（5 mg/kg body weight） administration of 5 different ivermectin injection.The ivermectin concentrations in plasma samples were determined by HPLC-UV.Pharmacokinetic analysis of plasma drug concentration-time data for ivermectin was carried out with a computer program 3P97.The ivermectin concentration-time data were fitted to one-compartment open model after single subcutaneous administration of ivermectin injection.The main pharmacokinetics parameters（E） were as T_1/2（Ka）（8.10±3.68）h,T_1/2（Ke）（36.34±14.63） h,T_max（22.38±8.63） h,C_max（354.01±57.75） ng/mL,AUC（25843±3029） ng/（mL·h）.The statistics analyzed by SPSS results showed there were no significant differences（P〉0.05） in T_1/2（Ka）,T_1/2（Ke）.However,pharmacokinetic of C_max was significant differences（P〈0.05）.Pharmacokinetics of AUC was higher than others,the results of present studies showed that the ivermectin injection demonstrated rapid absorption,rapid elimination,highly bioavailability.The safety of ivermectin in rabbits indicated that ivermectin injection satisfied clinical requirements cluded that supplementation of bacillus preparation in diets increased the antioxidant capacity and improve intestine microbial flora of layers.

关 键 词：伊维菌素 生物利用度 药代动力学 家兔 

分 类 号：S859[农业科学—临床兽医学]