他汀类药物应用于冠心病患者中的调脂干预效果研究  

Study on Lipid-lowering Intervention Effect of Statins Used in Patients with Coronary Heart Disease

作　　者：毕子宇 

机构地区：[1]河北省唐山工人医院分院,河北唐山063003

出　　处：《实用预防医学》2011年第11期2154-2155,共2页Practical Preventive Medicine

摘　　要：目的探讨他汀类药物治疗冠心病患者的临床疗效及调脂干预效果。方法将唐山工人医院分院内科69例患者随机分为治疗组35例和对照组34例,治疗组口服普伐他汀片,对照组口服鱼油,观察冠心病患者症状、心电图改善情况,并分别于治疗前、后测定血脂水平,组间进行比较分析。结果治疗后治疗组血脂水平与对照组比较明显下降,治疗组冠心病患者症状改善总有效率为94.3%、明显优于对照组的73.5%,治疗组心电图改善总有效率为68.6%、明显优于对照组的41.2%,两组间差异均有统计学意义(P<0.05)。结论他汀类药物降胆固醇作用明显,并且可以显著改善冠心病患者的心电图、症状及预后,应作为冠心病患者治疗的一线用药。Objective To explore the clinical therapeutic effect and lipid-lowering intervention effect of statins used in patients with coronary heart disease. Methods Sixty-nine patients hospitalized in Department of Internal Medicine,the Branch of Workers＇ Hospital of Tangshan were randomly divided into treatment group（n=35） and control group（n=34）.The patients in treatment group took pravastatin tablets orally,while the patients in control group took fish oil orally.The symptoms of coronary heart disease and ECG improvement in the patients were observed.The lipid levels of the patients were detected before and after the treatment.And the results were compared and analyzed between the two groups. Results After the treatment,compared with control group,the lipid levels of patients in treatment group were significantly decreased.The total effective rate of improving coronary artery disease symptoms of treatment group was 94.3%,which was significantly superior to control group（68.6%）.The total effective rate of ECG improvement of treatment group was significantly better than control group（41.2%）.There were statistically significant differences between the two groups（P0.05）. Conclusion Statins has a significant cholesterol-lowering effect;and moreover, it can significantly improve the electrocardiogram,symptoms and prognosis of patient with coronary heart disease.Statins should be used as the first-line agent in treatment of coronary heart disease.

关 键 词：冠心病 高血脂 他汀类药物 

分 类 号：R541.4[医药卫生—心血管疾病]