托特罗定联合膀胱训练治疗女性膀胱过度活动症  

Comparison of tolterodine with bladder training versus tolterodine alone for the treatment of women with overactive bladder syndrome

作　　者：何昌孝[1] 黄颖川[1] 王翰辉[1] 李冬[1] 袁正勇[1] 

机构地区：[1]都江堰市人民医院泌尿外科,四川都江堰611830

出　　处：《四川医学》2011年第11期1721-1723,共3页Sichuan Medical Journal

摘　　要：目的膀胱过度活动症(overactive bladder,OAB)是一种严重影响生活质量的慢性疾病,其治疗目的主要是改善症状及提高健康相关生活质量,本研究通过对219例女性膀胱过度活动症患者的前瞻性研究,探讨托特罗定联合膀胱训练治疗女性膀胱过度活动症的疗效及作用机制。方法在排除其它能引起贮尿期症状的原因后,共219例女性膀胱过度活动症患者连续被纳入研究,其中110例患者予以单用托特罗定治疗,109例患者予以托特罗定联合膀胱训练治疗。观察两组人群治疗前后OAB症状改善情况,从而提供一种较新的OAB治疗方法。结果对照组、实验组患者分别予以单用托特罗定、联合使用托特罗定和膀胱训练治疗4周后,实验组患者24h尿急次数平均减少2.5次(-38.5%),急迫性尿失禁次数减少1.5次(-75%),排尿次数减少2.9次(-29%),夜尿次数减少2次(-57.1%),每次排尿量增加60ml(36.4%);对照组24h尿急次数平均减少1.5(-25%)次,急迫性尿失禁次数减少0.8次(-36.4%),排尿次数减少1.8次(-15%),夜尿次数减少0.8次(-26.7%),每日排尿量增加35ml(22.2%)。两组患者OAB各症状改善情况差异均具有统计学意义(P<0.05)。结论托特罗定联合膀胱训练能明显改善女性OAB症状,提高患者生活质量。Objective Overactive bladder（OAB） is chronic condition that significantly affect quality of life in patients.The goal of treatment of OAB is to improve the lower urinary tract symptoms（LUTS） and enhance the quality of life.This study aims to investigate whether tolterodine combined with bladder training is more effective than tolterodine alone in the treatment of women with overactive bladder（OAB）,advancing the management of OAB via a prospective review of 219 female cases with OAB symptoms.Methods After we excluded other causes for storage symptoms,219 consecutive female patients with OAB were prospectively studied,of which 110 cases were given tolterodine alone while the other 109 cases were given tolterodine combined with bladder training for the treatment of OAB.Data on urgency,incontinence,micturition frequency,nocturia episodes and voided volume were collected before and after 4 weeks＇ treatment using a 3-day micturition diary.Results The two groups of OAB patients were given toterodine alone,toterodine combined with bladder training for 4 weeks respectively.At weeks 4,the number of urgency episodes per 24 hours in the intervention group decreased by 2.5（-38.5%）,incontinence episodes by 1.5（-75%）,micturitions by 2.9（-29%）,nocturia episodes by 2（-57.1%） and the volume voided per micturition increased by 60ml（36.4%）,while in the control group the number of urgency episodes per 24 hours decreased by 1.5（-25%）,incontinence episodes by 0.8（-36.4%）,micturitions by 1.8（-15%）,nocturia episodes by 0.8（-26.7%） and the volume voided per micturition increased by 35ml（22.2%）.The differences of changes of LUTS between the 2 groups has statistical significance（P0.05）.Conclusion A combination of toterodine and bladder training is a potential therapy for female patients with OAB,improving significantly the OAB symptoms.

关 键 词：托特罗定 膀胱训练 膀胱过度活动症 女性 

分 类 号：R694.5[医药卫生—泌尿科学]