胰高血糖素样肽1对心血管系统作用的研究进展  

Progress on Cardiovascular Actions of Glucagon-like Peptide-1

作　　者：李静波[1] 林静娜[1] 

机构地区：[1]天津市人民医院内分泌科,天津300121

出　　处：《心血管病学进展》2011年第6期840-843,共4页Advances in Cardiovascular Diseases

摘　　要：胰高血糖素样肽1是体内一种重要的肠促胰素,能够通过多种途径降低血糖,在调节葡萄糖稳态中起重要作用,可用于预防和治疗糖尿病。胰高血糖素样肽1的受体分布广泛,除了胰腺组织外,还分布于脑、肺脏、心脏、肾脏等。近年来对胰高血糖素样肽1的研究发现其对心血管系统具有保护作用,如调节心率、血压,改善血管内皮功能、舒张血管、改善心肌缺血、改善心功能等。对这些作用的研究将为临床治疗糖尿病和心血管疾病提供新的方法。Glucagon-like peptide-1（GLP-1） is an incretin that lowers blood glucose through several mechanisms,and plays an important role in the regulation of glucose homeostasis.GLP-1＇s function in glucose homeostasis may make it useful in the prevention and treatment of diabetes.GLP-1 may also be important in treating cardiac issues.The GLP-1 receptor is widely distributed in the body.It is found in the brain,lung,heart,kidney and the pancreas.Recent studies have shown that GLP-1 has a protective effect on the cardiovascular system.It has been found to regulate heart rate and blood pressure,relax vascular vessels,improve endothelial function,and protect ischemic myocardium.Abnormalities of cardiovascular systems are common in diabetic patients.Further research into the effects of GLP-1 throughout the human body may shed light on how it can be used in the treatment of diabetes and heart disease.

关 键 词：胰高血糖素样肽1 血压 血管内皮 心肌缺血 心力衰竭 

分 类 号：R587.1[医药卫生—内分泌]