电针对血管性痴呆大鼠行为学及组织内胆碱乙酰转移酶含量的影响  

Influence of Electroacupuncture on Behavior Sciences and Content of Choline Acetyltransferas in Hippocampus in Vascular Dementia Rats

作　　者：杨春壮[1] 马英[1] 王莹[1] 辛焕中[1,2] 张海燕[1,2] 

机构地区：[1]牡丹江医学院,牡丹江157011 [2]牡丹江医学院黑龙江省高校肿瘤疾病防治重点实验室

出　　处：《浙江中医药大学学报》2011年第4期584-586,共3页Journal of Zhejiang Chinese Medical University

基　　金：黑龙江省卫生厅医学科研课题(编号:2006-401)~~

摘　　要：[目的]观察电针对血管性痴呆(VD)大鼠行为学及血和海马内胆碱乙酰转移酶(ChAT)含量的影响,探讨其治疗血管性痴呆的机制。[方法]用双侧颈总动脉缺血—再灌注制作VD大鼠模型,将造模后大鼠随机分为模型组、电针组和西药组,并加以治疗。大鼠跳台检测行为学指标;酶免法检测血清和海马组织ChAT含量。[结果]电针组大鼠跳台检测反应期明显比模型级减少(P<0.05);电针组血清和海马组织ChAT含量比模型级提高(P<0.05)。[结论]电针能改善VD大鼠学习记忆能力,提高ChAT的含量,对VD大鼠血清和海马内ChAT含量的改善是电针治疗VD的机制之一。[Objective]To investigate the mechanism and observe the influence of electroacupuncture on Behavior sciences,content of Chorine Acetyltransferas（ChAT）in hippocampus in Vascular Dementia（VD）rats.[Methods]Using animals models of cerebral was chemiareperfusion—common carotid artery occlusion,the rats were randomized into model group,electroacupuncture group,western medicine group on treatment.The detection of Behavior sciences index by reaction of step down;The detection content of ChAT in hippocmpus and serum by enzyme—immunoassay method of rats.[Results]The detection of step down reaction period in electroacupuncture group was more decreased（P0.05）than model group;The content of ChAT in hippocampus and serum was more improved（P0.05）than model group.[Conclusion]Electroacupuncture could improve learning memory ability and ChAT contetment,one of mechanisms was improving content of ChAT in serum and hippocampus.

关 键 词：血管性痴呆 电针 行为学 胆碱乙酰转移酶 

分 类 号：R245.9[医药卫生—针灸推拿学]