倍他乐克早期静注治疗急性心肌梗死临床意义及其使用方法探讨  

The Study on Clinical Significance in Treatment of Acute Myocardial Infarction by Early Intravenous Metoprolol and Investigating the Method to Use

作　　者：王建平[1] 贺集贤[1] 何元军[1] 

机构地区：[1]四川省广元市中心医院心内科,四川广元628000

出　　处：《中国医药指南》2011年第32期8-9,共2页Guide of China Medicine

摘　　要：目的探讨早期静注倍他乐克治疗急性心肌梗死(AMI)的临床意义,探讨正确使用方法。方法将确诊为急性心肌梗死患者130例,按随机数字表分为倍他乐克组及对照组,每组各65例,对照组进行常规综合治疗,倍他乐克组在对照组的基础上,口服倍他乐克25mg/次,早晚1次,持续治疗2个月。比较两组临床效果,利用SPSS16.0进行统计分析。结果倍他乐克组室性心律失常、心率≤60次/min、心绞痛明显缓解的病例占比明显优于对照组,差异具有显著统计学意义,P<0.01;倍他乐克组平均心率、CK-MB值、CK-MB达峰时间、胸痛持续时间、心电图ST段回落时间、ST段抬高持续时间、EF值优于对照组,差异具有显著统计学意义,P均<0.01。结论急性心肌梗死患者早期应用倍他乐克能明显缩小心肌梗死面积,减轻缺血导致的胸痛,降低总病死率及心脏性猝死,有效改善预后,没有明显不良反应,耐受性好,值得临床推广应用,根据患者病情,可灵活使用不同给药方案。Objective To investigate the clinical significance of acute myocardial infarction by early intravenous metoprolol,and to investigating the proper use.Methods 130 acute myocardial infarction patients were randomly divided into the metoprolol group and control group,each group of 65 cases,the control group were treated by the routine treatment,metoprolol group were treated oral metoprolol tablet,25mg/times,2 times/day,continuous treatment for 2 months.Results The ventricular arrhythmias,heart rate≤60 beats/min,cardiogenic shock,death,angina relieved of metoprolol group were better than the control group,P0.01;the average heart rate,CK-MB values,CK-MB peak time,duration of chest pain,ECG ST segment time,ST-segment elevation duration,EF values of metoprolol group and the control group were better than the control group,the difference was statistically significant,P0.01.Conclusion Early use of metoprolol were given in acute myocardial infarction patients have important clinical significance,can significantly reduce myocardial infarct size,correct cardiac remodeling,reduce ischemia caused by chest pain,reduce total mortality and sudden cardiac death,improve prognosis,have no significant adverse reactions,tolerance is good,worthy of clinical application,according to the patient＇s condition,the flexibility to use different dosing regimens.

关 键 词：倍他乐克 急性心肌梗死 使用方法 

分 类 号：R542.22[医药卫生—心血管疾病]