新诊断2型糖尿病患者血清γ-谷氨酰基转移酶、抵抗素与胰岛素抵抗的关系研究  

Correlation of Serum γ-Glutamyltransferase,Resistin with Insulin Resistance in Newly Diagnosed Type 2 Diabetic Patients

作　　者：潘佳秋[1] 刘静[1] 李丽疆[1] 王慧慧[1] 

机构地区：[1]佳木斯大学附属第一医院内分泌科,黑龙江省佳木斯市154002

出　　处：《中国全科医学》2011年第31期3570-3572,共3页Chinese General Practice

摘　　要：目的探讨新诊断2型糖尿病(T2DM)患者血清抵抗素、γ-谷氨酰基转移酶(GGT)与胰岛素抵抗的关系。方法选取新诊断T2DM患者55例(T2DM组)及健康对照者34例(对照组),应用酶联免疫测定法检测血清抵抗素水平,同时测定空腹血糖(FPG)、GGT、胰岛素、血脂各项指标的水平。计算胰岛素抵抗指数(HOMA-IR)、胰岛素敏感指数(ISI)及胰岛β细胞功能指数(HOMA-β),对抵抗素、GGT及其他因素进行单因素相关分析,再进行多元逐步回归分析。结果 (1)新诊断T2DM患者血清抵抗素[(13.7±5.4)ng/ml]、GGT[(80.1±32.2)u/L]水平显著高于对照组[分别为(9.9±3.6)ng/ml、(25.6±15.7)u/L],差异有统计学意义(P<0.01)。(2)相关分析显示,GGT、抵抗素均与FPG、三酰甘油(TG)、HOMA-IR、体质指数(BMI)呈正相关(P<0.05),均与HOMA-β、ISI呈负相关(P<0.05),GGT与抵抗素呈正相关(P<0.05)。(3)多元逐步回归分析发现,GGT、TG、HOMA-IR为影响抵抗素的最显著因素,常数项为零。结论血清抵抗素、GGT可能参与胰岛素抵抗,可能在T2DM的发生、发展过程中起重要作用。Objective To investigate the relation of serum resistin,γ-glutamyltransferase（GGT） with insulin resistance in type 2 diabetes mellitus（T2DM） patients newly diagnosed. Methods A total of 55 T2DM patients and 34 non-diabetic controls were recruited.ELISA technique was employed to determine the serum resistin;at the same time the fasting blood glucose,GGT,insulin and blood lipid indexes were detected.The HOMA insulin resistance index（HOMA-IR）,insulin sensitive index（ISI）,and HOMA index of β-cell function（HOMA-β） were calculated.Univariate analysis was performed of resistin,GGT and other factors,and then multiple regression analysis.Results （1）The levels of serum resistin[（13.7±5.4）ng/ml] and GGT[（80.1±32.2）u/L] in newly diagnosed T2DM group were significantly higher compared with the control group [（9.9±3.6）ng/ml,（25.6±15.7）u/L,respectively]（P0.01）.（2）Correlation analysis revealed that the concentrations of serum resistin and GGT were correlated positively with fasting plasma glucose（FPG）,triglyceride（TG）,HOMA-IR,and body mass index（BMI）（P0.05）;and negatively with HOMA-β and ISI（P0.05）. Resistin was correlated positively with GGT（P0.05）.（3）Multiple regression analysis showed that GGT,TG and HOMA-IR were the most significant factors influencing resistin,the constant term was zero. Conclusion Serum resistin and GGT take part in the etiological factor of insulin resistance,and may play an important role in occurrence and development of T2DM.

关 键 词：糖尿病 2型 Γ-谷氨酰基转移酶 抵抗素 胰岛素抵抗 胰岛素敏感性指数 

分 类 号：R587.1[医药卫生—内分泌]