长期特异性免疫治疗对螨过敏儿童血清IgG4的影响  

Effect of long-term specific immunotherapy on serum IgG4 in mite allergic children

作　　者：吴亚斌[1] 周晓勤[1] 黄兆选[1] 

机构地区：[1]湖北省妇幼保健院儿科,湖北武汉430070

出　　处：《临床儿科杂志》2011年第11期1052-1054,共3页Journal of Clinical Pediatrics

摘　　要：目的探讨长期特异性免疫治疗对螨过敏儿童血清IgG4的影响。方法对60例过敏性哮喘和(或)过敏性鼻炎的患儿,予屋尘螨特异性过敏原免疫治疗,在治疗前、治疗16周、治疗1年和治疗3年时分别进行血清IgG4检测。结果随着治疗的进行,螨特异性IgG4显著增高(F=83.91,P<0.001),各时间段差异均有统计学意义(P均<0.01),并且以治疗剂量递增过程患儿血中螨特异性IgG4含量增长最快,在三年治疗结束时血清IgG4值达到最高。结论螨特异性过敏原免疫治疗对患儿体内免疫状态有明显的调节作用,有利于改善螨过敏患儿的症状和体征。Objective To study the effect of long-term specific immunotherapy on serum IgG4 in mite allergic children.Methods All 60 children with mite allergic asthma and/or mite allergic rhinitis were included.House dust mite allergen-specific immunotherapy was administered to them.The serum level of IgG4 was measured before and 16 weeks after treatment,1 year and 3 years after treatment.Results The serum level of mite-specific IgG4 in mite allergy children was significantly increased（F = 83.91,P〈 0.001）,and with significant differences between the four time points.Serum level of mite-specific IgG4 increased in a dose dependent manner.At the end of three-year-treatment,serum IgG4 level was found the highest.Conclusions Mite allergy-specific immunotherapy acts as a significant beneficial regulator in patients,which helps to improve the symptoms and signs related to mite allergy.

关 键 词：螨 特异性IGG4 儿童 

分 类 号：R725.6[医药卫生—儿科] R765.21[医药卫生—临床医学]