N-BOC-L-色氨酸分子印迹聚合物的手性拆分  

Molecular Imprinting Polymers for Chiral Separation of N-BOC-L-Trp

作　　者：于思明[1] 苏立强[1] 何丹凤[2] 

机构地区：[1]齐齐哈尔大学化学与化学工程学院,黑龙江齐齐哈尔161006 [2]大庆师范学院化工学院,黑龙江大庆163712

出　　处：《化工时刊》2011年第10期18-20,共3页Chemical Industry Times

基　　金：黑龙江省自然科学基金项目(B200911);黑龙江省教育厅科研项目(11533002)

摘　　要：以分散聚合法制备的聚苯乙烯微球为种子,采用单步溶胀悬浮聚合法,N-BOC-L-色氨酸为模板分子,丙烯酰胺为功能单体,乙二醇二甲基丙烯酸酯为交联剂,在水相中成功制备了分子印迹聚合物微球,吸附实验表明,印迹聚合物对模板N-BOC-L-色氨酸有良好的吸附性,该聚合物作为液谱固定相,实现了模板与其对映体的快速基线分离。The molecularly imprinted polymeric microspheresins（MIPMs） were prepared successfully via a single-step swelling in aqueous system,using polystyrene（which was prepared by dispersion polymerization technique） as seeds,N-BOC-L-Trp as template molecule,acrylamide as a functional monomer,and ethyleneglycol dimethacrylate as a cross-linking agent.The results of adsorption text showed that the prepared MIPMs exhibited high adsorption and good specific selectivity for N-BOC-L-Trp.Baseline chiral separation of the template enantiomer was achieved quickly,when using the polymer as chromatogram stationary phase.

关 键 词：分子印迹技术 种子溶胀 N-BOC-L-色氨酸 

分 类 号：O631.3[理学—高分子化学]