微波辅助合成4-氯-α-羟基-苯乙酸  

Microwave Assisted Synthesis of 4-Chloro-α-hydroxyphenylacetic Acid

作　　者：吴毅[1] 范谦 程珂 杨维清 李鸿波[1] 

机构地区：[1]西南科技大学材料科学与工程学院,四川绵阳621010 [2]利尔化学股份有限公司,四川绵阳621000

出　　处：《化工时刊》2011年第10期27-28,共2页Chemical Industry Times

摘　　要：以对氯苯乙腈为原料,经30%NaOH碱解得到对氯苯乙酸,再经NBS溴代,微波辅助下Na2CO3碱解,制得4-氯-α-羟基-苯乙酸。产品总收率达65.1%,纯度为97.5%。该路线避免了剧毒品氰化钠的使用和副产物对氯苯甲酸的产生,具有原料易得、处理简便、产品纯度高等优点。4-Chloro-α-hydroxyphenylacetic acid was prepared by alkaline hydrolysis of 4-chloro-benzeneacetonitrile as starting material in 30% NaOH,followed by the bromination with NBS and alkaline hydrolysis in Na2CO3 aqueous solution under microwave irradiation.The product was obtained in total yield 65.8%,purity 97.5%.This synthetic route avoids the using of cymag with high toxicity and the side product of 4-chlorobenzoic acid,so it has the advantages of cheap raw material,simple operation and high product purity.

关 键 词：对氯苯乙腈 4-氯-α-羟基-苯乙酸 微波 合成 

分 类 号：TQ245.12[化学工程—有机化工]