生地黄化学成分研究  

Chemical constituents from Rehmannia glutinosa

作　　者：李行诺[1] 周孟宇[1] 沈培强 张建兵 楚楚[1] 葛志伟[3] 颜继忠[1] 

机构地区：[1]浙江工业大学药学院,浙江杭州310014 [2]正大青春宝药业有限公司,浙江杭州310023 [3]浙江大学药学院,浙江杭州310058

出　　处：《中国中药杂志》2011年第22期3125-3129,共5页China Journal of Chinese Materia Medica

基　　金：国家"重大新药创制"科技重大专项(2009ZX09313-036)

摘　　要：目的:研究生地黄Rehmannia glutinosa干燥根的化学成分。方法:采用硅胶柱色谱结合制备高效液相进行分离和纯化,根据理化性质和波谱数据进行结构鉴定。结果:分离得到12个化合物,即5-hydroxymethyl-pyrrole-2-carbaldehyde(1),5-羟甲基糠醛(5-hydroxymethyl furfural,2),酪醇(tyrosol,3),5,6-二羟基-β-紫罗兰酮(5,6-dihydroxy-β-ionone,4),6-O-E-阿魏酰基筋骨草醇(6-O-E-feruloyl ajugol,5),麦角甾苷(acteoside,6),leucosceptoside A(7),地黄苷(martynoside,8),异地黄苷(isomar-tynoside,9),purpureaside C(10),jionoside A1(11),jionoside B1(12)。结论:化合物1,3,9为首次从该属植物中分离得到。Objective： To study the chemical constituents from the roots of Rehmannia glutinosa.Method： The compounds were isolated by various chromatographic methods and identified by spectroscopic analysis.Result：Twelve compounds were isolated and their structures were identified as 5-hydroxymethyl-pyrrole-2-carbaldehyde（1）,5-hydroxymethyl furfural（2）,tyrosol（3）,5,6-dihydroxy-β-ionone（4）,6-O-E-feruloyl ajugol（5）,acteoside（6）,leucosceptoside A（7）,martynoside（8）,isomartynoside（9）,purpureaside C（10）,jionoside A1（11）,and jionoside B1（12）.Conclusion： Compounds 1,3 and 9 were isolated from the genus Rehmannia for the first time.

关 键 词：生地黄 化学成分 苯乙醇苷 

分 类 号：R284[医药卫生—中药学]