檀香叶黄酮类化学成分研究  

Study of flavonoids from leaves of Santalum album

作　　者：闫冲[1,2] 林励[1] 刘红菊[2] 林志新[2] 陈盘余[2] 蔡聪 郑来安 

机构地区：[1]广州中医药大学中药学院,广东广州510006 [2]广东医学院药学院,广东东莞523808 [3]广东省湛江南药试验场,广东湛江524338

出　　处：《中国中药杂志》2011年第22期3130-3133,共4页China Journal of Chinese Materia Medica

基　　金：高等学校博士学科点专项科研基金项目(20094425110009);广东省中医药局科研课题(2010409);广东高校优秀青年创新人才培养计划项目

摘　　要：目的:研究檀香Santalum album叶中黄酮类成分,为檀香叶的资源开发提供理论依据。方法:檀香叶的70%乙醇回流提取物经大孔吸附树脂、聚酰胺、Sephadex LH-20等柱色谱法分离纯化,现代波谱技术鉴定化合物化学结构。结果:分离得到8个黄酮类成分,分别鉴定为芹菜素-6,8-二-C-β-D-葡萄糖苷(1),牡荆苷(2),异牡荆苷(3),荭草苷(4),异荭草苷(5),白杨素-8-C-葡萄糖苷(6),白杨素-6-C-葡萄糖苷(7),异鼠李素(8)。结论:所获得的8个成分均为首次从檀香中分离得到,其中7个为结构相似的黄酮碳苷类成分,并形成了3对同分异构体。Objective： To study the flavonoids from the leaves of Santalum album.Method： The sample was extracted with 70% ethanol by continuous thermal reflux.The extraction was separated and purified by column chromatography over macroporous adsorption resin,polyamide and sephadexlh-20.Their structures were identified by detailed spectroscopic analysis.Result： Eight flavonoids were isolated and identified as vicenin-2（1）,vitexin（2）,isovitexin（3）,orientin（4）,isoorientin（5）.chrysin-8-C-β-D-glucopyranoside（6）,chrysin-6-C-β-D-glucopyranoside（7）,and isorhamnetin（8）.Conclusion： All compounds were isolated from this plant for the first time.

关 键 词：檀香叶 黄酮 化学成分 鉴定 

分 类 号：R284[医药卫生—中药学]