新生儿高胆红素血症听觉多频稳态诱发反应分析  

Multiple-frequency auditory steady-state evoked responses of newborn with hyperbilirubinemia

作　　者：康爱建[1] 顾红兵[1] 

机构地区：[1]南通大学附属妇幼保健院儿科,江苏南通226006

出　　处：《南京医科大学学报（自然科学版）》2011年第10期1448-1450,共3页Journal of Nanjing Medical University(Natural Sciences)

基　　金：南通市卫生局科技计划项目(W0518)

摘　　要：目的:通过听觉多频稳态诱发反应分析,探讨高胆红素血症对新生儿中枢神经的影响。方法:对280例血总胆红素(TBC)≥220.6μmol/L(12.9 mg/dl)的足月新生儿临床资料及听觉多频稳态诱发反应(ASSR)的检测结果进行回顾性分析。结果:TBC≤310.0μmol/L 195例,ASSR均正常;>520.0μmol/L 18例均发生胆红素脑病,其中ASSR中重度以上异常16例;310.1～519.9μmol/L67例,均无脑病临床表现,但ASSR出现异常,其中轻-中度异常63例(94.0%),中重度以上异常2例。听觉多频稳态诱发反应异常程度与TBC及TBC与白蛋白比(TB/A)有关(P<0.01),与高胆红素病因构成无关(P>0.05)。结论:听觉多频稳态诱发反应可早期发现亚临床胆红素神经中毒症,建议血胆红素浓度≥307.8μmol/L时,ASSR应列入常规检查。Objective： To study the influence of hyperbilirubinemia upon newborns central nervous system by pass multiple-frequency auditory steady-state evoked responses analysis.Methods： Clinical data and examination results of multiple-frequency auditory steady-state evoked responses（ASSR） of 280 cases,blood total bilirubin consistency（TBC） higher than 220.6 μmol/L（12.9 mg/dl） month newborns,were retrospectively reviewed.Results： One hundred and ninty-five cases with TBC less than 310.0 μmol/L,had normal ASSR;18 cases with TBC higher than 520.0 μmol/L all took place encephalpathy of bilirubin,among them,16 cases of ASSR were heavy degree abnormal;67 cases with TBC less than 519.9 μmol/L or higher than 310.1 μmol/L,had no encephalopathy clinical performance,but ASSR appeard an abnormality,among them,63 cases（94.0%） were light-mid-degree abnormal,2 cases were heavy degree abnormal.The abnormality degree of ASSR is related with TBC,TBC and albumin ratio（TB/A）（P 0.01）,but wasn＇t related to the constituent of pathogenesis of hyperbilirubinemia（P 0.05）.Conclusion： ASSR can suggest preclinical nervous poisonsing of hyperbilirubinemia in early stage,when TBC is higher than 307.8 μmol/L,ASSR should be included as a normal test.

关 键 词：新生儿 听觉多频稳态诱发反应 高胆红素血症 

分 类 号：R722.1[医药卫生—儿科]