初发2型糖尿病患者血清25-羟维生素D水平及相关性研究  

Blood serum level of 25-hydroxy-vitamin D in initial type 2 diabetes mellitus

作　　者：丁怡[1] 丁国宪[1] 钱珂[2] 唐暎[3] 汪心水[3] 张俊[4] 刘息平[4] 

机构地区：[1]南京医科大学第一附属医院老年医学科,江苏南京210029 [2]苏州大学附属第三医院老年科,江苏常州213001 [3]苏州大学附属第三医院内分泌科,江苏常州213001 [4]苏州大学附属第三医院综合实验室,江苏常州213001

出　　处：《南京医科大学学报（自然科学版）》2011年第10期1451-1454,1470,共5页Journal of Nanjing Medical University(Natural Sciences)

基　　金：南京医科大学第一附属医院创新团队面上项目(代谢与衰老研究)

摘　　要：目的:比较初发2型糖尿病患者(T2DM)血清维生素D、人体参数、生化指标与正常对照组的差异,分析维生素D与人体参数、生化指标的相关性,探讨维生素D在早期2型糖尿病发生中的作用及意义。方法:选择初诊T2DM患者65例,同期健康体检者32例,比较两组患者血清25(OH)D水平以及人体参数和生化指标;比较T2DM伴低25(OH)D组和T2DM不伴低25(OH)D组的腰围、BMI、FBS、HbA1C、血压、生化指标及PTH水平。结果:初发T2DM患者血清25(OH)D水平明显低于正常对照组,在维生素D的相关性分析中,25(OH)D与BMI、TG、Apo-A1呈负相关,与HDL-C呈正相关,与血压、血糖、HbA1C无明显的相关性。T2DM患者的PTH水平较对照组明显增高,且与维生素D水平呈负相关。结论:初发T2DM患者的血清维生素D水平较正常对照组降低,尤其是伴有肥胖、血脂异常者的血清维生素D水平降低更明显。但是初发T2DM患者的维生素D水平与血压、空腹血糖、钙离子、糖化血红蛋白无明显相关性。T2DM患者更易并发高血压的原因可能与PTH的增高有关,其机制有待进一步研究。Objective： To explore the role of vitamin D in the pathogenesis of initial type2 diabetes mellitus（T2DM） by comparing the difference of blood serum 25-hydroxy-vitamin D[25（OH）D],clinical and biochemical indexes between initial T2DM and normal persons.Methods： Sixty-five patients with T2DM were enrolled and divided into T2DM A group and T2DM B group according to the level of serum 25（OH）D,and 32 healthy people were selected as control.The levels of serum 25（OH）D,clinical and biochemical indexes were compared between two groups,and the difference of relative indexes including waistline,BMI,SBP,DBP,FBS,HbA1C,PTH were compared.Results： The level of serum 25（OH）D in the case group was significantly lower than that in the control group.Serum 25（OH）D was nagetively related to BMI,TG,Apo-A1 and PTH,and was positively related to HDL-C.There was no relationship between hypovitaminosis D and blood pressure,glucose or HbA1C.Conclusion： The level of serum 25（OH）D in the patients with initial T2DM was low,especially with obesity and abnormality in blood-fat.There was no relationship between serum 25（OH）D and blood pressure,glucose,calcium or glycosylated hemoglobin.The reason that T2DM patients were easily complicated by hypertension was possibly related to the rise of PTH,and the mechanism is expected to study.

关 键 词：初发2型糖尿病 维生素D 25羟维生素D 糖化血红蛋白 甲状旁腺激素 

分 类 号：R587.1[医药卫生—内分泌]