2008-2010年南京及周边地区儿童肺炎支原体感染情况分析  

Investigation of Mycoplasma Pneumoniae infection in children from Nanjing and surrounding areas from 2008 to 2010

作　　者：王晓卫[1] 钟天鹰[2] 岳玉林[2] 陈晓军[1] 苏川[1] 

机构地区：[1]南京医科大学病原生物学系,江苏省现代病原生物学重点实验室,江苏南京210029 [2]南京医科大学附属南京儿童医院检验科,江苏南京210008

出　　处：《南京医科大学学报（自然科学版）》2011年第10期1463-1465,1537,共4页Journal of Nanjing Medical University(Natural Sciences)

基　　金：国家自然科学基金资助(81071385)

摘　　要：目的:分析南京及周边地区儿童肺炎支原体(MP)感染的流行病学特征,为该病的预防和治疗提供帮助。方法:采用血清MP被动凝集法对2008年1月至2010年12月在南京医科大学附属南京儿童医院门诊就诊的急性呼吸道感染患儿进行MP-IgM抗体检测,并结合病例资料进行分析。结果:三年间共检测血清标本31843例,总阳性率为41.35%;2008年阳性率最高,达45.08%;≤1岁、1-3岁、3-5岁、>5岁的患儿MP-IgM抗体阳性率分别为9.90%、32.48%、38.24%、57.57%;男性患儿为36.08%,女性患儿为48.16%;春、夏、秋、冬四季阳性率分别为39.56%、36.51%、42.11%、48.69%。结论:MP可能为南京地区儿童呼吸道感染的重要病原之一。MP感染全年均可发生,尤以冬季感染率为高;婴儿感染率较低,而学龄儿童感染率最高;女性患儿感染率高于男性患儿。本研究的结果初步揭示了南京及周边地区MP感染的流行病学特征,对该地区MP的预防和治疗有一定价值。Objective： Analysis of infection rate of mycoplasma pneumonia（MP） in Nanjing and surrounding areas are made in order to probe into epidemic characteristics of MP infection in this area.At the same time it offers help for prevention and treatment of the disease.Methods： Child outpatients with respiratory infection from Nanjing or surrounding areas in Nanjing Children＇s Hospital Affiliated to Nanjing Medical University from January 2008 to December 2010 were subject to serum MP passive agglutination method to test MP-IgM antibody.Statistical analysis of MP-IgM antibody test result based on clinical data was made.Results： 31843 serum samples were tested during the three years.Out of them 13166 samples were positive,MP-IgM antibody with the positive rate being 41.35%;The positive rate in 2008 was the highest covering 45.08% of the total child patients infected with respiratory diseases in a year;Positive rate of MP-IgM antibody of children whose age was below or equal to 1 years old was 9.90%;From 1 to 3 years old was 32.48%;From 3 to 5 years old was 38.24%;Over 5 years old was 57.57%;Positive rate of male child patients was 36.08% and female child patients was 48.16%;On the other hand,Positive rate in the spring was 39.56%;In the summer was 36.51%;In the autumn was 42.11%;In the winter was 48.69%.Conclusion： MP is the main causative pathogen for respiratory infection of children in Nanjing area.MP infection goes on throughout the year with infection rate in the winter being the highest;Infection rate of infants is the lowest while that of preschool children is the highest;Infection rate of female child patients is higher than that of male child patients.The result of this study uncovers the epidemic characteristics of MP infection in Nanjing and surrounding areas,which is of significance for prevention and treatment of MP in this area.

关 键 词：肺炎支原体 儿童 呼吸道感染 

分 类 号：R969.3[医药卫生—药理学]