左旋多巴醇在不对称还原中的应用研究  

Applied Research on L-dopa Alcohol in Asymmetric Reduction

作　　者：冯瑞[1] 

机构地区：[1]河南南阳医学高等专科学校,河南南阳473058

出　　处：《化工技术与开发》2011年第11期5-6,63,共3页Technology & Development of Chemical Industry

基　　金：广西科学基金项目资助(桂科基0575055)

摘　　要：在NaBH4/Cd2+、NaBH4/Co2+、NaBH4/Ce3+、NaBH4/Ni3+还原体系中,采用加入手性源左旋多巴醇和不加入左旋多巴醇两种方法,分别对苯乙酮进行不对称还原,结果表明,加入手性源左旋多巴醇后,反应速度快,产率高。同时在这4种还原体系中NaBH4/Ce3+的催化效果最好。Asymmetric reduction of acetophentone was prepared by two methods of adding L-dopa Alcohol or no adding L-dopa alcohol with NaBH4/Cd2＋ 、NaBH4/Co2＋ 、NaBH4/Ce3＋ 、NaBH4/Ni3＋ as the reducing agent.The optimum conditions were as followed： the method of adding L-dopa alcohol had the advantages of faster reaction speed and higher yield.At the same time,with NaBH4/Ce3＋ as the reducing agent was the best of catalytic effect in the four reduction system.

关 键 词：左旋多巴醇 苯乙酮 不对称还原 

分 类 号：TQ031[化学工程]