安徽省儿童乙型肝炎病毒感染状况及影响因素研究  

A Study on Epidemic Status and Influences of Hepatitis B Virus among Children in Anhui Province

作　　者：唐继海[1] 罗献伟[1] 刘丹青[1] 沈永刚[1] 陆志坚[1] 王斌冰[1] 赵月萍[1] 陈晓琴[1] 周淑洁[1] 陈霞[1] 晏开力[1] 王建军[1] 戴振威[1] 任军[1] 

机构地区：[1]安徽省疾病预防控制中心,合肥230061

出　　处：《中国疫苗和免疫》2011年第5期404-407,共4页Chinese Journal of Vaccines and Immunization

摘　　要：目的了解安徽省乙型肝炎(乙肝)病毒(Hepatitis B Virus,HBV)感染状况,评价儿童乙肝疫苗(HepatitisB Vaccine,HepB)纳入免疫规划管理取得的效果。方法按多阶段随机抽样方法,对安徽省6个县(区)1～14岁儿童进行流行病学调查并采集血标本,用酶联免疫吸附试验检测HBV感染标志。结果在1340份血清标本中,乙肝病毒表面抗原(HBV Surface Antigen,HBsAg)标化阳性率为1.95%,抗乙肝病毒表面抗原抗体标化阳性率为62.07%,抗乙肝病毒核心抗原抗体标化阳性率为5.50%,HBV感染率为11.93%;1～14岁儿童HepB标化接种率为87.14%;城市和农村儿童标化接种率分别为92.04%和80.76%。结论安徽省儿童HBsAg阳性率和HBV感染率下降明显,HepB纳入免疫规划管理14年来效果显著。Objective To understand epidemic status of hepatitis B virus and measure the effects of immunization activities over the last 14-years,seroepidemiological study among children aged 1-14 year-old was conducted in Anhui province.Methods Cross-section seroepidemiologic survey was conducted and the samples were collected by multi-section randomly from 6 counties in Anhui province.Serological biomarkers to hepatitis B virus（HBV）were tested using enzyme-linked immunosorbent assay reagents.Results Among 1340 children,the adjusted prevalence rates of HBV surface antigen（HBsAg）,antibody to HBsAg,antibody to HBV Core antigen and HBV infection were 1.95%、62.07%、5.50% and 11.93% respectively.The hepatitis B vaccine adjusted coverage rate was 87.14% in children aged 1-14 years,and of them the rate was 92.04% in urban and 80.76% in rural areas.Conclusion The prevalence rates of HBsAg and HBV infection have obviously declined in children aged 1-14 years.It has achieved great success to integrate HepB into expanded program for immunization over the past 14 years.

关 键 词：1~14岁儿童 乙型肝炎病毒感染 血清流行病学 乙型肝炎疫苗 预防接种 

分 类 号：R512.62[医药卫生—内科学] R186[医药卫生—临床医学]