大规模含风疹成份疫苗接种后对人群风疹免疫水平的影响  

Impact of Population Immunity to Rubella after the Mass Immunization of Rubella Antigen Contained Vaccine

作　　者：赵艳荣[1] 何寒青[1] 冯燕[1] 陈恩富[1] 李倩[1] 朱建慧[2] 吴逸平[3] 李清[4] 李岩林 郑晓华[6] 

机构地区：[1]浙江省疾病预防控制中心,杭州310051 [2]杭州市下城区疾病预防控制中心,浙江杭州310003 [3]慈溪市疾病预防控制中心,浙江慈溪315300 [4]海宁市疾病预防控制中心,浙江海宁314400 [5]衢州市衢江区疾病预防控制中心,浙江衢州324022 [6]仙居县疾病预防控制中心,浙江仙居317300

出　　处：《中国疫苗和免疫》2011年第5期416-419,共4页Chinese Journal of Vaccines and Immunization

摘　　要：目的了解含风疹成份疫苗(Rubella Contained Vaccine,RCV)大规模接种后,对人群风疹免疫水平的影响。方法对浙江省2009年全人群风疹免疫水平监测数据进行分析。结果全人群风疹抗体阳性率为67.52%,几何平均浓度(Geometric Mean Concentration,GMC)为20.04国际单位/毫升(IU/ml),以4～7月龄最低,2～4岁最高,15～39岁女性抗体阳性率为67.82%。有RCV免疫史者中,97.36%集中于8月龄～19岁。其中8～23月龄、2～4岁组有免疫史的比例明显高于其他年龄组。有RCV免疫史及风疹患病史人群免疫水平明显升高。8月龄～2岁常规免疫覆盖人群中,有1剂、2剂次RCV免疫史者风疹抗体GMC均高于无免疫史者,但两者间的差异无统计学意义(P=0.085)。<20岁各年龄组风疹免疫水平与发病率基本上呈反比。结论常规免疫覆盖人群风疹免疫水平较使用疫苗前明显提高,发病率明显下降。而青少年及成人风疹免疫水平却较使用疫苗前有不同程度下降。Objective To know the impact of population immunity to Rubella after mass immunization with rubella contained vaccine（RCV）in Zhejiang province.Methods Surveillance data on population immunity to rubella in 2009 were analyzed.Results The rubella seropositive rate was 67.52%,and the geometric mean concentration（GMC）was 20.04IU/ml,the lowest age group is in 4-7 months and the highest was in 2-4 year group.The seropositive rate was 67.82% in female aged 15-39 years.Most RCV immunized persons（97.36%）was in 8 months to 19 years,the history of immunization among 8-23 months and 2-4 years was higher than other age group.Rubella immunity was increased significantly in persons with history of RCV vaccination or rubella infection.Among children aged 8 months to 2 years,GMC of rubella antibody in the children with 1 or 2 doses of RCV,which had no statistically difference between children with 2 doses RCV immunization and those with 1 dose RCV immunization（P=0.085）,but both of them were higher than those had no RCV history.Among persons 20 years,there was almost a negative correlation of rubella immunity and incidence rate.Conclusion Antibody of Rubella is obviously higher in the population with RCV immunization than those before administered RCV immunization and incidence of them decreased as well.However,the Rubella antibody in adolescents and adults was decreased.

关 键 词：含风疹成份疫苗 全人群 大规模接种 风疹免疫水平 

分 类 号：R511.2[医药卫生—内科学] R186[医药卫生—临床医学]