大鼠下颌下腺卵泡刺激素受体、雌激素α受体的分布及与促性腺激素释放激素受体的共存  

Distribution of FSHR and ER α and their colocalization with GnRHR in rat submaxilary gland

作　　者：于辉[1] 

机构地区：[1]山东德州学院医学系,山东德州253023

出　　处：《解剖科学进展》2011年第6期582-585,589,共5页Progress of Anatomical Sciences

基　　金：山东省自然科学基金资助项目(ZR2011CL001);德州学院校级科研课题资助项目(318092)

摘　　要：目的研究卵泡刺激素受体(FSHR)和雌激素α受体(ERα)在大鼠下颌下腺中的定位、分布及与促性腺激素释放激素受体(GnRHR)共存。方法采用免疫组织化学定位和邻片免疫组织化学共定位方法。结果大鼠下颌下腺浆液性腺泡及各级导管的上皮细胞均呈FSHR和ERα免疫反应阳性;在下颌下腺GnRHR免疫反应阳性细胞中观察到了FSHR免疫反应阳性的结果,其中大部分亦呈ERα免疫反应阳性,且分布模式相同;三种免疫反应阳性物质均分布在细胞质内,细胞核呈阴性。结论 GnRHR与FSHR或ERα在大鼠下颌下腺共存提示他们对下颌下腺具有重要的生理调节功能。Objective To investigate the distribution of follicle-stimulating hormone receptor（FSHR）,estrogen receptorα（ERα）and colocalization with gonadotropin releasing hormone receptor（GnRHR）in rat submaxilary glands.Methods Distribution of FSHR and ERα and their colocalization with GnRHR in rat submaxilary glands were investigated by immunohistochemical method.Results FSHR and ERα immunoreactivities were observed in the cytoplasm of the epithelial cells of serous acinus and various tubes in rat submaxilary gland respectively with negative nucleus.The colocalization of FSHR or ERα with GnRHR immunoreactivities was also found in the same structures of two adjacent section.Conclusion The colocalization of FSHR or ERα with GnRHR indicates that they might play an important role in rat submaxilary gland.

关 键 词：卵泡刺激素受体 雌激素Α受体 促性腺激素释放激素受体 免疫组织化学 大鼠下颌下腺 

分 类 号：R333.1[医药卫生—人体生理学]