蒺藜总皂苷对AD大鼠的影响  

Effect of Total Saponins of Tribulus Terrestris L.on Alzheimer's Disease Rats

作　　者：王永斌[1] 甘云波[1] 

机构地区：[1]咸宁学院基础医学院,湖北咸宁437100

出　　处：《咸宁学院学报（医学版）》2011年第5期379-381,共3页Journal of Xianning Univarsity(medical Sciences)

基　　金：湖北省教育厅中青年基金项目:Q20092802

摘　　要：目的探讨蒺藜总皂苷对WT/GFX致AD大鼠空间记忆的影响。方法采用侧脑室注射WT/GFX制作AD大鼠模型,Morris水迷宫检测大鼠空间记忆能力。结果蒺藜总皂苷明显缩短大鼠寻找平台的时间,搜寻策略也得以改善。结论蒺藜总皂苷能有效改善因WT/GFX所致的大鼠空间记忆障碍。Objective To investigate the effect of total saponins of Tribulus terrestris L.（GSTT） on spatial memory of Alzheimer＇s disease（AD） rats induced by WT/GFX.Methods The AD model was established by ventricular injection of wortmannin（WT,a specific PI3K inhibitor） and GF-109203X（GFX,a specific PKC inhibitor）,and the patial memory ability was detected by Morris water maze task.Results It was shown that the swimming latency was increased significantly after WT/GFX injection.Compared with AD group,GSTT could significantly shorten WT/GFX-induced the increase of swimming latency,improved the searching strategy of rats for platform.Conclusion These results suggest that GSTT can effectively prevent the rats from WT/GFX-induced spatial memory deficits.

关 键 词：蒺藜总皂苷 老年性痴呆 空间记忆 

分 类 号：R285.5[医药卫生—中药学]