茯苓、甘草、银花复方制剂对砷中毒小鼠治疗效果的实验研究  

Curative Effects of Compound Preparation of Hoelen,Sweet Root and Flos Lonicerae in Mice with Arsenic Poisoning

作　　者：覃淑云[1] 张树球[2] 

机构地区：[1]柳州医学高等专科学校,广西柳州545006 [2]右江民族医学院,广西百色533000

出　　处：《工业卫生与职业病》2011年第6期352-354,共3页Industrial Health and Occupational Diseases

摘　　要：目的观察茯苓、甘草、银花复方制剂对砷中毒小鼠治疗效果,寻找一种安全有效无毒的治疗砷中毒药物。方法建立砷中毒小鼠动物模型,按随机方法将小鼠分为对照组、砷中毒组和治疗组;治疗组先行染砷再给予茯苓、甘草、银花复方制剂进行治疗;各组处理60d后测定血清中超氧化物歧化酶(SOD)活力、谷胱甘肽(GSH)和肌酐(Cr)含量;行肝脏、肾脏组织切片,光镜观察肝、肾损害程度。结果砷中毒组小鼠SOD活力下降[(129.86±37.23)UN/ml],GSH含量降低[(172.16±30.08)mg/L],Cr含量升高[(123.56±23.69)μmol/L],小鼠肝、肾脏损害严重;治疗组SOD活力、GSH和Cr含量明显恢复,分别是(189.68±47.16)UN/ml、(266.29±58.45)mg/L、(86.75±16.08)μmol/L,肝脏、肾脏损害明显减轻。结论茯苓、甘草、银花复方制剂对染砷中毒小鼠具有明显的治疗效果。ObjectiveTo observe the effects of compound preparation of hoelen,sweet root,and flos lonicerae in mice with arsenic poisoning and to search an effective medicine for treating arsenic poisoning. MethodsMice were used to establish the arsenic poisoning models.Mice were randomly divided into namely the control group,arsenic poisoned group and treatment group.In the treatment group,mice were first poisoned with arsenic,afterward the mice were treated with compound preparation of hoelen,sweet root and flos lonicerae.The serum glutathione（GSH）,superoxide dismutase（SOD）and creatinine（Cr）were measured after 60 days.The organ damages of liver,kidney were studied under light microscope. Results In the arsenic poisoned group,the vitality of SOD（129.86±37.23 UN/ml）and the contents of GSH（172.16±30.08 mg/L）lowered while the Cr contents elevated（123.56±23.69 umol/L）.The histological damages of liver and kidney were significant.In the treatment group,the vitality of SOD,the contents of GSH and Cr obviously recovered,（189.68±47.16 UN/ml）,（266.29±58.45 mg/L）,and（86.75±16.08 umol/L）respectively.The histological damages of liver and kidney were repaired. ConclusionsResults show obvious curative effects of compound preparation of hoelen,sweet root and flos lonicerae on arsenic poisoning in mice.

关 键 词：茯苓 甘草 银花复方制剂 砷中毒 治疗效果 

分 类 号：R113[医药卫生—公共卫生与预防医学]