乳腺纤维腺瘤病灶中钙化的矿物学研究  

A Mineralogical Study on Calcification in Fibroadenoma of Breast

作　　者：熊翠娥[1] 王长秋[1] 鲁安怀[1] 李艳[1] 梅放[2] 柳剑英[2] 朱梅倩[1] 张波[2] 

机构地区：[1]北京大学造山带与地壳演化教育部重点实验室地球与空间科学学院,北京100871 [2]北京大学医学部基础医学院病理学系,北京100083

出　　处：《矿物学报》2011年第4期713-718,共6页Acta Mineralogica Sinica

基　　金：国家自然科学基金项目(批准号:40872196);国家重点基础研究发展计划资助项目(973项目)(2007CB815602)

摘　　要：选取8例乳腺纤维腺瘤的钙化样品,利用光学显微镜(OM)、环境扫描电镜(ESEM)、高分辨透射电镜(HR-TEM)、显微红外光谱仪(FTIR)、微区X射线衍射等矿物学方法对样品进行了原位和分离后形貌、结构及成分的测试分析,探讨了病灶中钙化的矿物学特征,初步探讨了钙化的组成及形成机理。研究结果表明,乳腺纤维腺瘤中的钙化是由病变后期玻璃样变性胶原中的羟基和羧基为钙化提供了成核位点,伴随病情发展最后形成OM下可见的以羟磷灰石为主要成分的坏死钙化。In this paper,calcifications in the calcified focus from fibroadenoma of breast patients were investigated in terms of their composition,structure and morphology,by using light microscope（OM）,environmental scanning electron microscope（ESEM）,high resolution transmission electron microscope（HR-TEM）,fourier transform infrared spectroscopy（FTIR） and microarea X-ray diffraction.The formation mechanism of the calcifications was also discussed.The results show that in the early stage of calcifications in fibroadenoma of breast,many nano-sized calcified balls were precipitated on the collagen fibers due to the adsorption of inorganic ions such as calcium ions to glucose amino glycan.These balls continued to grow and aggregate,and gradually induced the calcification of the collagen fibers during the development of disease,which finally turned out to be large areas of hydroxylapatite calcifications that can be seen under OM.

关 键 词：乳腺纤维腺瘤 钙化 羟磷灰石 矿物学 

分 类 号：P571[天文地球—矿物学] P578.92[天文地球—地质学]