子痫前期对氧磷酶1活性和代谢综合征变量变化的临床研究  

Changes of Serum Paraoxonase1 Activities and Metabolic Syndrome Varibles in Preeclamptic Women

作　　者：董淑晓[1] 王立方[1] 辛虹[1] 

机构地区：[1]河北医科大学第二医院,河北石家庄050000

出　　处：《实用妇产科杂志》2011年第11期866-869,共4页Journal of Practical Obstetrics and Gynecology

摘　　要：目的:研究子痫前期患者血清对氧磷酶1(PON-1)活性及代谢综合征变量的变化和发生情况。方法:选择年龄、孕周、产次相匹配的轻度子痫前期患者38例(MPE组),重度子痫前期患者45例(SPE组),正常孕妇63例(对照组)为研究对象,测定其血清PON-1活性、丙二醛(MDA)、血脂及空腹血糖水平等指标。结果:子痫前期患者(MPE组+SPE组)血清MDA、总胆固醇、甘油三酯、低密度脂蛋白水平(LDL)均明显高于对照组(P<0.05),而血清PON-1活性及高密度脂蛋白(HDL)较对照组明显降低(P<0.05);SPE组空腹血糖较MPE组和对照组明显升高(P均<0.05)。子痫前期患者血清PON-1活性与MDA、甘油三酯、LDL水平呈负相关(P均<0.05),与HDL水平呈正相关(P<0.05),与BMI及空腹血糖无明显相关性(P>0.05)。对照组、MPE组及SPE组代谢综合征的发生率分别为3.2%,18.4%,33.3%。结论:子痫前期患者有代谢综合征的标志,推断两种疾病相互关联。子痫前期患者血清PON-1活性显著降低,可能为两种疾病相互关联的重要原因之一。Objective：To explore the activity of paraoxonase and changes of metabolic syndrome variables in preeclamptic women. Methods：38 pregnant women with mild preeclampsia （MPE）, 45 women with severe preeclampsia （SPE）, and 63 normal pregnant women as control were recruited in this study after the age, gestination age and parity were matched. Fasting serum paraoxonase （PON1） activity was determined, as well as malondialdehyde （MDA）, plasma lipids, fasting blood glucose and blood pressure. Results：Patients with preeclampsia had significantly higher serum MDA, total cholesterol, triglycerides, low density lipoprotein levels compared with the control group （P〈0.05）, but the serum paraoxonase 1 activity and high-density lipoprotein in preeclamptic patients were significantly lower than those in the control group （ P〈0.05）. Pations in the SPE group had significantlg higher fasting blood glocose then the MPE and control group（ P 〈 0.05）. Serum PON-1 activity in preeclamptic patients was negatively correlated with serum MDA, triglycerides, LDL levels （ P 〈 0.05）, while it was positively correlated with serum HDL levels （ P〈0.05）, no significant correlation with BMI and fasting blood glucose （ P 〉0.05）. The incidence of metabolic syndrome in control group, MPE and SPE were 3.2%, 18.4%, 33.3% respectively. Conclusions： Preeclampsia presents the characteristics of metabolic syndrome, so these are two correlated disease. Signifi- cantly decreased serum PON-1 activity in preeclamptic patients might be the reason of correlation of the two diseases.

关 键 词：子痫前期 对氧磷酶1 代谢综合征 

分 类 号：R714.24[医药卫生—妇产科学]