不可分型流感嗜血杆菌候选疫苗的研究进展  

RESEARCH PROGRESS ON NONTYPEABLE HAEMOPHILUS INFLUENZAE VACCINE CANDIDATES

作　　者：何多姣[1] 张彦霞[1] 贾天军[1] 张玉妥[1] 

机构地区：[1]河北北方学院病原生物与免疫学研究所,张家口075000

出　　处：《现代预防医学》2011年第23期4958-4960,共3页Modern Preventive Medicine

摘　　要：不可分型流感嗜血杆菌(nontypeable Haemophilus influenzae,NTHi)是多种感染性疾病如急性中耳炎,鼻窦炎,结膜炎,慢性支气管炎的常见病原菌,近年来随着NTHi菌株耐药性的增强,NTHi感染已经成为全球一个较严重的健康问题,因此目前亟待研究一种安全有效的疫苗来预防NTHi的感染。多种NTHi的抗原被作为抗NTHi感染的候选疫苗来研究,该文主要针对近年来的一些研究热点如外膜蛋白P6/P5/P2/P26、Haps蛋白、HMW蛋白(high molecularweight protein,HMW protein)等进行综述,为后续疫苗的研制提供一些依据。Nontypeable Haemophilus influenzae（NTHi）is a commonly causative pathogen for many infectious diseases,such as acute otitis media,sinusitis,conjunctivitis,chronic bronchitis and so on.With a recent increase in antibiotic resistance of NTHi,infection caused by NTHi has been a serious global health problem,so it is high time to develop a safe and effective vaccine to prevent against NTHi infection.Many antigens of NTHi have been evaluated as vaccine candidates for NTHi,this article will present a conclusion of research highlights such as outer membrane protein P6/P5/P2/P26,Haps protein,HMW protein（high molecular weight protein）for the past few years to offer some foundations for the follow-up vaccine studies.

关 键 词：不可分型流感嗜血杆菌 候选疫苗 外膜蛋白 动物模型 

分 类 号：R186[医药卫生—流行病学]