咪达普利联合比索洛尔治疗慢性心力衰竭的临床疗效  

Clinical efficacy of imidapril combined with bisoprolol in the treatment of chronic heart failure

作　　者：张子云[1] 邢志娟[1] 王利平[1] 李予文[1] 路世红[1] 王田田[1] 

机构地区：[1]河南宏力医院心内科,长垣453400

出　　处：《中国实用医刊》2011年第23期23-24,共2页Chinese Journal of Practical Medicine

摘　　要：目的观察咪达普利联合比索洛尔治疗慢性心力衰竭（CHF）的疗效。方法入选CHF患者260例，其中对照组108例，在一般治疗基础上加用卡托普利、阿替洛尔；试验组152例，在一般治疗基础上加用咪达普利、比索洛尔；比较各组治疗前后及两组间脑钠肽（BNP）、超敏c反应蛋白（hs-CRP）、左室舒张末期内径（LVEDD）、左室射血分数（LVEF）、6min步行试验（6MWT）的变化。结果治疗后两组BNP、hs-CRP、LVEDD明显下降（P〈0．05），LVEF、6MWT明显提高（P〈0．05）。与对照组相比，试验组BNP下降、LVEF和6MWT提高更明显（P〈0．05）。结论咪达普利联合比索洛尔治疗慢性心力衰竭效果更显著。Objective To observe the efficacy of imidapril combined with bisoprolol in the treatment of chronic heart failure（CHF）. Methods Two hundred and sixty patients with CHF were divided into two groups, 108 cases of control group, captopril combined with atenolol based on the general treatment, 152 cases of treatment group, imidapril combined with bisoprolol based on the general treatment. BNP,hs- CRP, LVEDD, LVEF,6 MWT were compared between the two groups. Results In the two groups, brain natriuretie peptide （ BNP）, high sensitivity C reactive protein （ hs - CRP） and left ventricular end - diastolic dimension （LVEDD） was obviously decreased （ P 〈 0. 05 ） , while left ventricular ejection fraction （LVEF）and six- minute walk test（6 MWT） was obviously improved （ P 〈 0.05 ）. The declining of BNP, and increase of LVEF and 6 MWT in the treatment group was more obviously than the control group （ P 〈 0. 05 ）. Conclusions Imidapril combined with bisoprolol in the treatment of chronic heart failure must be much more effective.

关 键 词：咪达普利 比索洛尔 慢性心力衰竭 脑钠肽 6 MIN步行试验 

分 类 号：R541.6[医药卫生—心血管疾病]