淫羊藿苷药理作用的分子机制研究进展  

Icariin and its pharmaceutical efficacy:research progress of molecular mechanism

作　　者：陈洋[1] 黄建华[1] 宁友[1] 沈自尹[1] 

机构地区：[1]复旦大学华山医院中西医结合研究所,上海200040

出　　处：《中西医结合学报》2011年第11期1179-1184,共6页Journal of Chinese Integrative Medicine

基　　金：国家重点基础研究发展计划(973计划)资助项目(No.2010CB530400);国家自然科学基金资助项目(No.30901888;No.30873319)

摘　　要：淫羊藿苷是补肾要药淫羊藿的主要药效成分之一,具有抗神经元损伤、促神经突触生长、促成骨、抗炎症、抗肿瘤、提高性功能和抗抑郁等作用。为了解淫羊藿苷发挥药理效应的分子机制,本文检索了1995年1月1日至2011年5月1日PubMed数据库中收录的题目中含"icariin"的文献共122篇,发现淫羊藿苷可通过影响丝裂原活化蛋白激酶/p38信号通路和磷脂酰肌醇3激酶/Akt信号通路,作为磷酸二酯酶5抑制剂和核受体调节剂发挥作用。本文还进一步分析了研究淫羊藿苷分子机制的主要方向。Icariin is one of the key active components of Epimedium species, which is most widely applied to supplement the kidney in traditional Chinese medicine. Scientific research has found that icariin possesses extensive therapeutic effects such as protecting neurons from injury, promoting growth of neuronal synapse, improving sexual dysfunction and bone morphogenesis, as well as anti-inflammation, anti-tumor and anti- depression functions. Considering that molecular mechanism is the fundamental basis for pharmaceutical efficacy of icariin, in this article, the authors retrospectively retrieved 122 scientific papers recorded in the PubMed database with＂icariin＂ in the title from January 1, 1995 to January 5, 2011. It was found that icariin has been closely highlighted in the intervention of p38 mitogen-activated protein kinases and phosphatidylinositol 3-kinase/Akt signal pathways, inhibition of phosphodiesterase 5, and regulation of nuclear receptors. Besides, the authors also discussed the main orientation for molecular mechanism of icariin in future research.

关 键 词：淫羊藿苷 MAP激酶2信号系统 信号转导 环核苷酸磷酸二酯酶类 5型 磷酸二 酯酶抑制剂 受体 类固醇 综述 

分 类 号：R285[医药卫生—中药学]