针刺联合车前番泻颗粒治疗功能性便秘的随机对照研究  

Acupuncture combined with Chinese herbal medicine Plantain and Senna Granule in treatment of functional constipation:a randomized,controlled trial

作　　者：郭李柯[1] 张超贤[2] 郭晓凤[3] 

机构地区：[1]新乡医学院第一附属医院口腔内科,河南卫辉453100 [2]新乡医学院第一附属医院消化内科,河南卫辉453100 [3]杭州市第六人民医院肝病科,浙江杭州310014

出　　处：《中西医结合学报》2011年第11期1206-1214,共9页Journal of Chinese Integrative Medicine

摘　　要：背景:功能性便秘是最常见的消化系统疾病之一,目前尚无有效的西医治疗方案,严重影响人们的生活质量。中西医结合疗法对功能性便秘有较好的治疗效果。目的:探讨针刺联合车前番泻颗粒治疗功能性便秘的临床疗效。设计、场所、对象和干预措施:2008年2月至2010年1月来自新乡医学院第一附属医院消化科门诊和病房的390例确诊的功能性便秘患者采用随机方法分为3组:针刺组、车前番泻颗粒组和联合治疗组,每组130例。针刺组针刺天枢、上巨虚、足三里、大肠俞及支沟穴,每日2次,共4周;车前番泻颗粒组予车前番泻颗粒5 g口服,每日1次;联合治疗组则予上述针刺及车前番泻颗粒治疗。主要结局指标:评价3组患者治疗前、治疗结束时及治疗后64周排便周期、大便性状、排便困难症状及伴随症状和胃肠传输时间(包括全胃肠传输时间、口-盲时间、结肠传输时间、右半结肠传输时间、左半结肠传输时间及直肠乙状结肠传输时间)。结果:治疗过程中针刺组脱落3例,剔除2例;车前番泻颗粒组脱落2例,剔除3例;联合治疗组脱落2例。与治疗前比较,治疗结束时各组排便周期、大便性状、排便困难症状及伴随症状评分,胃肠传输时间均明显下降(P<0.01),联合治疗组上述指标优于其他组(P<0.05);与治疗结束时比较,治疗后64周上述指标在针刺组和联合治疗组无明显反复(P>0.05),在车前番泻颗粒组则有明显反复(P<0.05);联合治疗组近期和远期总有效率均显著高于其他组(P<0.05,P<0.01)。各组均无严重不良反应发生。结论:针刺和车前番泻颗粒均能显著缩短功能性便秘患者的胃肠传输时间和排便周期,改变大便性状,缓解排便困难症状及伴随症状,但联合治疗效果更好,并具有较好的安全性和耐受性。Background： Functional constipation is one of the most common gastrointestinal diseases. Currently, there is no effective Western medical therapy for functional constipation and it significantly impacts the quality of life of the patients. Integrated traditional Chinese and Western medicine therapies were reported to have better therapeutic effects than routine Western medicine therapies. Objective： To explore the efficacy of acupuncture combined with Chinese herbal medicine Plantain and Senna Granule in the treatment of functional constipation. Design, setting, participants and interventions： A total of 390 patients with confirmed functional constipation enrolled from the Department of Gastroenterology, the First Affiliated Hospital of Xinxiang Medical College in China from February 2008 to January 2010 were randomly divided into three groups, with 130 cases in each group. Acupuncture group was treated with puncture of point Tianshu （ST25）, Shangjuxu （ST37）, Zusanli （ST36）, Dachangyu （BL25） and Zhigou （S J6） twice daily for four weeks, while Plantain and Senna Granule group was treated with 5 g of Plantain and Senna Granule once daily, and the combination group was given above-mentioned acupuncture and Plantain and Senna Granule. Main outcome measures： The defecation cycle, stool property, constipation symptom, accompanying symptoms, gastrointestinal transit time, including total gastrointestinal transit time, mouth-intestine transit time, colonic transit time, right colonic transit time, left colonic transit time and rectosigmoid colonic transit time, and adverse reactions of the three groups were evaluated before treatment, at the end of treatment and 64 weeks after treatment, respectively. Results： Compared with before treatment, the scores of defecation cycle, stool property, constipation symptoms and accompanying symptoms, and gastrointestinal transit time all decreased significantly at the end of treatment in each group （P〈0.01）, and the combination group showed better r

关 键 词：针刺 中成药 功能性便秘 排便次数 大便性状 排便困难症状 伴随症状 胃肠传输时间 

分 类 号：R246[医药卫生—针灸推拿学] R256.35[医药卫生—中医临床基础]