阿立哌唑辅助治疗抗精神病药引发的高催乳素血症的对照研究  

A Placebo-Controlled Trial of Adjunctive Treatment with Aripiprazole for Risperidone-induced Hyperprolactinemia

作　　者：刘亮[1] 祁曙光[1] 董小惠[1] 蒋德珍[1] 崔凤伟[1] 潘乾洪 

机构地区：[1]中国．江苏省无锡市精神卫生中心临床精神科,214151

出　　处：《中国健康心理学杂志》2011年第11期1288-1290,共3页China Journal of Health Psychology

摘　　要：目的探讨合并小剂量阿立哌唑对利培酮引起的高催乳素血症的治疗作用。方法选择长期住院,且服用利培酮治疗导致高催乳素血症的缓解期精神分裂症患者86例,随机分成3组,分别合并阿立哌唑5m g,阿立哌唑10m g,安慰剂(对照组)进行4周对照研究。分别于治疗第0、1、4周末测定血清PRL水平,并采用阳性和阴性症状量表(PANSS)、锥体外系症状量表(ESRS)、副反应量表(TESS)评定疗效和不良反应。结果阿立哌唑5m g组(F=28.625,P<0.01)、阿立哌唑10m g组(F=61.412,P<0.01)治疗第1周末、第4周末PRL血清水平与治疗前相比均存在显著差异;对照组第1、4周末PRL血清水平均无显著变化。3组不良反应均较轻,总体发生率相当,对利培酮的疗效均无不良影响。结论合并小剂量阿立哌唑可显著降低利培酮引起的催乳素水平升高,安全性较高。Objective To explore the efficacy and tolerability of aripiprazole in the adjunctive treatment for risperidone-induced hyperprolactinemia.Methods A total of 68 schizophrenia patients with hyperprolactinemia taking risperidone were enrolled.Risperidone dose was fixed;aripiprazole was dosed at 5 mg/day,10 mg/day for 4 weeks.Serum prolactin levels were measured at weeks 0,1,4.Symptoms and side effects were assessed with Positive and Negative Syndrome Scale（PANSS）,Extrapyramidal Symptom Rating Scale（ESRS）,Treatment Emergent Symptom Scale（TESS） at weeks 0,1,4.Results Serum prolactin levels were reduced significantly at the first week,and the fourth week（F=28.625,P0.01） in aripiprazole group dosed at 5 mg/day;and also reduced significantly at the first week,and the fourth week（F=61.412,P0.01） in aripiprazole group dosed at 10 mg/day;however this difference in placebo group was not statistically significant before and after the study.Other side effects were mild and the total prevalence of side effects was similar in all the groups.Conclusion Efficacy and tolerability of aripiprazole in the adjunctive treatment for risperidone-induced hyperprolactinemia is very good.

关 键 词：精神分裂症 高催乳素血症 利培酮 阿立哌唑 

分 类 号：R584[医药卫生—内分泌]