常用465味中药材、饮片不良反应/事件文献分析  

Analysis of Adverse Reaction/Events Induced by 465 Chinese Crude Drug and Chinese Herbal Pieces on the Literature

作　　者：刘欣[1] 金锐[1] 崔一然[1] 张倩[1] 张冰[1] 

机构地区：[1]北京中医药大学,北京100029

出　　处：《中国药物警戒》2011年第12期731-734,共4页Chinese Journal of Pharmacovigilance

基　　金：国家科技部"十一五"科技支撑计划课题(2006BA121B11)

摘　　要：目的基于文献报道,对常用465味中药不良反应/事件进行分析和总结。方法通过文献检索,收集中药材/饮片不良反应报道文献,应用文献计量学和统计学方法对中药材、饮片不良反应情况进行分析。结果检索常用中药饮片465味,共收集不良反应文献报道1 256篇,病例数8 560例。对上述文献报道进行逐一筛选,发现真正由于常规用法用量、正确给药途径导致不良反应的中药饮片177味,文献716篇,共2 208例。根据文献报道分析,中药材/饮片不良反应发生的主要原因是剂量过大、服用时间过长、炮制过程中的接触及个体差异等。而在常规用法、用量条件下,中药饮片发生不良反应的报道相对较少,且主要集中在过敏体质人群和被普遍认为无不良反应的药物中。对于有毒中药饮片进行检索,发现不良反应报道较少,这可能是由于大家对其防范的结果。结论对于中药材/中药饮片的不良反应,既不应夸大,也不能忽视,应该客观的认识和评价其不良反应。Objective To analyze and summarize the adverse reactions or vent information of 465 traditional Chinese drugs Based on reported in the literature. Methods The reports in the literature of Chinese Crude Drug/Chinese Herbal Pieces were searched and analyzed by bibliornetrics and statistic methods. Results The 1 256 reports about adverse reactions with 8 560 cases were collected, in the 465 Conamon Chinese Herbal Pieces. By analyzing again, It was found that 177 Chinese Herbal Pieces, 716 literatures, 2 208 clinical cases in the usage of convention and the correct route of administration. According to reported in the literature analysis, Chinese Crude Drug/Chinese Herbal Pieces adverse reactions take place mainly due to excessive doses, length time, in the process of Concocting and individual difference and so on. In the convention usage and dosage, Chinese Herbal Pieces reports of adverse reactions is relatively small, and mainly concentrated in the allergic population and is generally considered the drugs which were not regarded as adverse reactions. Fewer report adverse reactions about toxic traditional Chinese medicine was found, due to the results of all of its prevention. Conclusion I believe that the Chinese Crude Drug/Chinese Herbal Pieces of adverse reactions should be neither exaggerated nor ignored and should be an objective understanding and evaluation of Chinese Herbal Pieces of adverse reactions.

关 键 词：中药材 中药饮片 不良反应/事件 

分 类 号：R282[医药卫生—中药学] R994.11[医药卫生—中医学]