肠内营养支持在急性重症胰腺炎治疗中的应用  

Enteral nutrition support for treatment of severe acute pancreatitis

作　　者：方喜[1] 李颖[1] 蔡楚东[1] 彭淮都[1] 张俊烁[1] 吴俊伟[1] 肖亮生[2] 

机构地区：[1]广东省汕头市中心医院普通外科,515041 [2]广东省汕头市中心医院检验科,515041

出　　处：《广东医学》2011年第17期2257-2259,共3页Guangdong Medical Journal

基　　金：广东省医学科研基金资助项目(编号:A2009642)

摘　　要：目的比较肠内营养(EN)及肠外营养(TPN)支持治疗对重症急性胰腺炎的临床效果。方法将82例重症急性胰腺炎患者随机分为EN组和TPN组,分别应用EN和TPN治疗,比较两组临床数据、生化指标的改变以及感染率、病死率、住院时间及费用。结果两组血清白蛋白、血清前白蛋白、血清转铁蛋白较前显著升高(P<0.05);患者血浆D-乳酸、二胺氧化酶水平、血浆内毒素及尿乳果糖/甘露醇于EN治疗后较TPN明显下降,感染率、住院时间及费用均低于TPN,差异有统计学意义。结论重症急性胰腺炎患者尽早给予EN是安全有效的,较TPN能够获得较好的营养状态、更少的并发症、更高的生存率、更短的住院时间。Objective To compare the clinical efficacy of enteral nutrition （EN） and total parenteral nutrition （TPN） supports in patients with severe acute pancreatitis （SAP）. Methods Eighty - two patients with SAP were randomized into 2 groups. EN and TPN were given to patients in Group A and B, respectively. The chnical data, biochemical marker levels, infection, mortality, hospital stay and cost were recorded for analysis. Results In both groups, serum albumin, prealbumin, and serum transferring were significantly increased （P 〈 0.05）. However, significantly lower plasma D - lactate, diamine oxidase, endotoxin, and the urinary L/M ratio were revealed in Group A than those in Group B （P 〈 0.05）. Furthermore, less infection events, shorter hospital stay and lower cost were observed in Group A than those in Group B （P 〈 0.05）. Conclusion Early EN support for patients with SAP is safe and effective, and can improve nutri- tional status, reduce complications and mortality, and shorten hospital stay.

关 键 词：肠内营养 急性重症胰腺炎 疗效 

分 类 号：R459.3[医药卫生—治疗学]