含吲哚美辛宫内节育器中吲哚美辛的作用及其机制  

Effect of Indomethacin Contained in the Indomethacin-releasing Intrauterine Device and Its Mechanism

作　　者：修瑞杰[1] 顾向应[1] 

机构地区：[1]天津医科大学总医院妇产科,300052

出　　处：《国际生殖健康／计划生育杂志》2011年第6期454-457,共4页Journal of International Reproductive Health/Family Planning

摘　　要：宫内节育器(IUD)是中国育龄妇女使用最广泛的避孕工具,经量增多、经间点滴出血是IUD的主要不良反应。含吲哚美辛的IUD不仅能发挥良好的避孕效果,而且能避免置器后经量增多、经间点滴出血的不良反应。大量研究表明,吲哚美辛能抑制哺乳动物排卵。因此,研究者对这类含有吲哚美辛IUD的作用机制有了新的认识和探讨空间,即含吲哚美辛的IUD是否有抑制女性排卵、抑制卵子受精的作用。Intrauterine device（IUD） is the most widely used contraceptive method in fertile woman in China.The main side effects of IUD are hypermenorrhea and bit bleeding in menstrual interphase.Indomethacin-releasing IUD is a efficient contraceptive,efficaciously preventing those side effects.A lot of study suggested that indomethacin inhibited ovulation in mammals.It is necessary to study the effects of inclomthacin-releasing IUD and its new mechanism to clarify whether indomethacin-releasing IUD inhibit ovulation and fertilization in the human famale.

关 键 词：宫内避孕器 含药 吲哚美辛 避孕 药理作用分子作用机制 月经过多 

分 类 号：R169.41[医药卫生—公共卫生与预防医学]