孤核受体NR4A1参与能量代谢的调节  

NR4A1 Orphan Nuclear Receptors Modulate the Energy Metabolism

作　　者：董丽[1] 崔毓桂[1] 刘嘉茵[1] 

机构地区：[1]南京医科大学第一附属医院临床生殖医学中心,210029

出　　处：《国际生殖健康／计划生育杂志》2011年第6期458-461,共4页Journal of International Reproductive Health/Family Planning

摘　　要：孤核受体NR4A1(nuclear receptor subfamily4,group A,member 1)是核受体超家族中的一员,在多种细胞中表达,同时功能十分广泛,不仅参与细胞周期调控(增殖或凋亡),还与神经性疾病、类固醇激素的生成、肿瘤以及动脉粥样硬化的形成及能量调控密切相关。近年来,NR4A1与能量代谢的关系逐渐引起人们的广泛关注,在能量平衡调控中发挥了重要作用。Orphan nuclear receptor NR4A1,a member of the nuclear receptor superfamily,is widely expressed in different cell types.NR4A1 mediates diverse biological processes,such as cell cycle（proliferation or apoptosis）,formation of steroid hormone and is involved,NR4A1 was closely related with neurological diseases,tumor,atherosclerosis.Recently,emerging evidence suggested that NR4A1 played an important role in the transcriptional regulation of energy metabolism and balance.

关 键 词：能量代谢 肌 骨骼 胰岛素抗药性 糖尿病 葡萄糖代谢障碍 

分 类 号：R341[医药卫生—基础医学]