糖尿病肾病发病机制研究进展  

Research Progress in the Pathogenesis of Diabetic Nephropathy

作　　者：廖钰[1] 夏宁[1] 

机构地区：[1]广西医科大学第一附属医院代谢糖尿病中心,南宁530021

出　　处：《医学综述》2011年第22期3453-3455,共3页Medical Recapitulate

摘　　要：糖尿病肾病(DN)是糖尿病的主要并发症和终末期肾脏疾病的主要死亡原因之一,其发病率逐年上升。DN发病机制复杂,目前尚未完全清楚,其中涉及血流动力学改变、糖代谢紊乱及由此所致的非酶糖基化、多元醇通路激活、血管活性物质及细胞因子激活、氧化应激、蛋白激酶C激活、激肽释放酶-激肽系统作用、脂代谢紊乱、遗传等多个因素的相互作用,在此就DN的发病机制最近的研究进展予以综述。Diabetic nephropathy（DN）is the main complication of diabetes and a major cause of death at the end-stage renal disease,its incidence is increasing year by year.Yet,the pathogenic mechanisms underlying the development of DN are not completely clear,with multiple factors involved such as the hemodynamic changes,glycometabolism disorders and aldose reductase pathway activation,alterations in vasoactive substances and cytokines,oxidative stress and protein kinase C activation,the kallikrein-kinin system effects,lipid metabolism disorders,and genetic susceptibility,etc..The interaction of the above all kinds of factors involved in the pathogenesis of DN,and the recent research progress of DN pathogenesis are to be reviewed.

关 键 词：糖尿病 糖尿病肾病 发病机制 肾小球硬化 激肽释放酶-激肽系统 

分 类 号：R587.1[医药卫生—内分泌]