药物模拟心肌缺血后适应的研究进展  

Progression of Drug-simulated Research on Myocardial Ischemic Postconditioning

作　　者：纪超[1] 刘颖[1] 

机构地区：[1]广东药学院基础学院病理生理教研室,广州510006

出　　处：《医学综述》2011年第22期3456-3459,共4页Medical Recapitulate

基　　金：广东省科技计划项目(2008B060600055)

摘　　要：应用缺血后适应(IPost)的机制进行药物后适应的开发研究成为临床治疗缺血性心脏疾病的研究热点。IPost的发生机制与其激发心肌内源性活性物质的释放、启动保护性信号转导通路密切相关。目前已发现许多药物通过多个信号转导通路证实参与IPost的发生。现就能够模拟心肌IPost发挥保护缺血心肌作用的相关药物、信号转导通路的最新研究进展作一综述。Application of adaptive mechanisms after ischemic postconditioning（Ipost）for the research and development of post-adaptation of drug is becoming the hot research topic of clinical treatment of Ipost heart disease.Ipost occurrence mechanism and itsstimulating the release of cardiac endogenous substances,and starting protection signal transduction pathway are closely related.It has been found that many drugs are involved in the occurrence of Ipost through multiple signal transduction pathways.Here is to review the recent progress of research of related drugs and signal transduction pathways which can simulate myocardial Ipost protective role in myocardial ischemia.

关 键 词：药物后适应 心肌缺血再灌注损伤 心肌保护 

分 类 号：R542.22[医药卫生—心血管疾病]